Design of Medicines Flashcards
What is the main problem with small production?
Small scale products cannot be as well controlled as large scale
Formulation converts drug into medicine that have 3 attributes, what are they?
Bioavailability, stability + efficacy
State the factors affecting safety of medicines
Correct drug, dose + delivery method
Drugs have a therapeutic action. State the +ve and _ve effects
\+ve = medicinal purposes -ve = side effects
State what to consider in drug formulation and manufacture
- Functioning equipment
- Safe formula
- Correct calcs
- Safe + reliable materials
- Records kept safe
- Labelling + packaging
Define shelf-life
Period during which the product is expected to maintain unchanged physical + chemical properties
State the types of degradation
- Chemical, physical & microbiological
What can occur in a deflocculated suspension?
Caking
What can occur in a flocculated suspension?
Sedimentation
How long is the shelf life for an extemporaneous product?
1 month
List formulation considerations
- Physical + chemical stability, expiration dates, storage, preservatives
List manufacturing considerations
Clean containers not affecting strength, purity or quality, labelling
Oral powders are given in bulk/individually wrapped to supply potent/non-potent drugs and bulk/individually wrapped to supply potent/non-potent drugs
bulk
potent
individually wrapped
potent
List advantages of powders
- Solid is more stable than liquid
- Faster dissolution than tablets/capsules
- Convenient to dispense drugs with large doses
List disadvantages of powders
- Inconvenient for patients to carry
- Hard to mask unpleasant taste
- Unsuitable for potent drugs
- Unsuitable for drugs inactivated in stomach
