Design of Medicines Flashcards
What is the main problem with small production?
Small scale products cannot be as well controlled as large scale
Formulation converts drug into medicine that have 3 attributes, what are they?
Bioavailability, stability + efficacy
State the factors affecting safety of medicines
Correct drug, dose + delivery method
Drugs have a therapeutic action. State the +ve and _ve effects
\+ve = medicinal purposes -ve = side effects
State what to consider in drug formulation and manufacture
- Functioning equipment
- Safe formula
- Correct calcs
- Safe + reliable materials
- Records kept safe
- Labelling + packaging
Define shelf-life
Period during which the product is expected to maintain unchanged physical + chemical properties
State the types of degradation
- Chemical, physical & microbiological
What can occur in a deflocculated suspension?
Caking
What can occur in a flocculated suspension?
Sedimentation
How long is the shelf life for an extemporaneous product?
1 month
List formulation considerations
- Physical + chemical stability, expiration dates, storage, preservatives
List manufacturing considerations
Clean containers not affecting strength, purity or quality, labelling
Oral powders are given in bulk/individually wrapped to supply potent/non-potent drugs and bulk/individually wrapped to supply potent/non-potent drugs
bulk
potent
individually wrapped
potent
List advantages of powders
- Solid is more stable than liquid
- Faster dissolution than tablets/capsules
- Convenient to dispense drugs with large doses
List disadvantages of powders
- Inconvenient for patients to carry
- Hard to mask unpleasant taste
- Unsuitable for potent drugs
- Unsuitable for drugs inactivated in stomach
List the steps involved in the preparation of powders
Weighing
Measuring
Sifting
Mixing
Why design of medicines is important?
To manage disease
What are extemporaneous preparations
Medicines prepared for depending on a request from a prescriber for a specific patient
What must be checked before the release of a medicine?
- Design
- Quality
- Safety
Hygroscopic & deliquescent powders should be ______ ______ for protection
double wrapped
Solid dosage forms are more/less stable than liquids.
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