Protein folding Flashcards
1
Q
What is Phi?
A
N-Ca bond
2
Q
What is Psi?
A
Ca-C bond
3
Q
The peptide bond can’t rotate but what can?
A
The bonds on each side
4
Q
For allow rotations around the peptide bond, state the charge of phi and psi
A
Phi = nearly always -ve (except in left-hand helix) psi = can be +ve/-ve
5
Q
State the charges for the geometry associated with the peptide bond
A
Clockwise = +ve angle Anticlockwise = -ve angle
6
Q
What is unfolded(U)?
A
Diverse population of structures
no structure preference
7
Q
What is native (N)?
A
one structure
8
Q
Folding goes from a high/low energy state to a lower/higher energy state?
A
high
lower
9
Q
What is the preferential conformation?
A
Native state
10
Q
Protein increases/decreases the whole system entropy by disorganising the water molecules around the unfolded state
A
increases
11
Q
What happens at midpoint?
A
50% of the molecular population still knows how to fold
12
Q
Are you making or breaking bonds when folding?
A
No
