Therapeutics - HIV part 2 Flashcards
name 4 types of entry inhibitors
fusion inhibitor
CCR5 antagonist
post attachment inhibitor
attachment inhibitor
name a fusion inhibitor
enfuviritide
name a CCR5 antagonist
maraviroc
name a post attachment inhibitor
ibalizumab
name an attachment inhibitor
fostemsavir
in general, what is the role in therapy for entry inhibitors
usually reserved for people who are failing the other classes of antiretrovirals, with the exception of maraviroc - may be used besides in failing therapy
***which HIV drug has a need for tropism testing? why? what class is it?
MARAVIROC
it’s a CCR5 antagonist - therefore, it will only work on a CCR5 tropic virus and we need to test for this
true or false
ALL of the entry inhibitors can be taken with or without food
true
true or false
there is no concern with CYP450 interactions with entry inhibitors
FALSE - there is for most of them
fostemsavir + ethinyl estradiol
what class is fostemsavir?
attachment inhibitor
levels of ethinyl estradiol will increase
true or false
several entry inhibitors are given by injection
true
enfuvirtide, ibalizumab
which entry inhibitor has a BBW of hepatotoxicity
maraviroc
name 5 integrase inhibitors
raltegravir
bictegravir
elvitegravir
dolutegravir
cabotegravir
true or false
integrase inhibitors are not used often
FALSE - they are
not a lot of side effects, they work well, and resistance is pretty rare
only integrase inhibitor that MUST be taken with food
(all others are with or without)
elvitegravir
which 2 integrase inhibitors undergo UGTA1A1 glucuronidation
cabotegravir and raltegravir
which integrase inhibitor’s use is restricted only to those whose creatinine clearance is over 70mL/min?
raltegravir
which 2 integrase inhibitors have CYP450 interaction concern?? which additionally has a binding interaction concern?
elvitegravir and dolutegravir
dolutegravir
which integrase inhibitor causes neural tube defects in utero?
dolutegravir
what class is considered last line therapy for HIV
capsid inhibitors - they’re new and not really used yet at all in practice – only for heavily experienced adults with multi-drug resistance HIV infection
name the only capsid inhibitor
lenacapavir
what is lenacapavir contraindicated with?
strong CYP3A4 inducers
it is a moderate CYP3A4 inhibitor
true or false
lenacapavir can be taken with or without food
true
HAART meaning
highly active antiretroviral therapy