Therapeutic Drug Monitoring

Question 1

Digoxin

Answer 1

CHF/Arrhythmia, renal

Question 2

Quinidine

Answer 2

Arrhythmia, Oral Hep

Question 3

Aminoglycosides

Answer 3

G(=/+), IV/IM, renal

Question 4

Vancomycin

Answer 4

G(+), renal, IV

Question 5

Phenobarbital

Answer 5

Slow, GI 10 hr, both renal and hep

Question 6

Phenytoin

Answer 6

Seizure/brain damage, oral hep, 90% protein bound

Question 7

Valproic

Answer 7

Petit mal/absence seizures, GI, 93% bound

Question 8

Lithium

Answer 8

Cationic metal no binding, Renal and reabsorb, no lithium heparin tube

Question 9

Tricyclic Antidepressants (TCA)

Answer 9

total tricyclic, 2-4 week steady state, Oral Hep

Question 10

Cyclosporine

Answer 10

GVHD, Oral Hep 5-50% absorption, 98%, sequester in RBC, WB sample

Question 11

Methotrexate

Answer 11

Inhibit DNA synth, Leocovorin reverse

Question 12

Theophylline

Answer 12

Asthma/Chronic obstructive pulmonary disease, both