therapeutic drug monitoring Flashcards
specimen for TDM
SERUM (commonly used)
plasma
whole blood
Cardioactive Drugs
Digoxin Procainamide Lidocane (xylocane) Quinidine Disopyramide Propanolol Amiodarone Verapamil
alters cardiac ions cardioactive drug
Digoxin
lowers BP & cardiac output cardioactive drug
Lidocane (xylocane)
blood dyscrasia cardioactive drug
Quinidine
lupus-like syndrome cardioactive drug
Procainamide
Antibiotics
Aminoglycosides
Vancomycin
Chloramphenicol
Antibiotic that is for Gram (-) ; protein synthesis inhibitors, and assoc. w/ blood dyscrasia
Chloramphenicol
cell wall inhibitor, againstGram (+) , nephro-&ototoxicity
Vancomycin
“red man syndrome”
Vancomycin
Antiepileptic drugs
Phenytoin Valproic acid Carbamazepine Ethosuximide (Zantin) Neurontin (Gabapentin)
nystagmus
Neurontin (Gabapentin)
pancreatitis
Valproic acid
initiation of seizure
Phenytoin
Bronchodilator
Theophylline
Immunosuppressor
Cyclosporin
Tacrolimus
Rapamycin
Immunosuppressor drug testing specimen
Whole blood EDTA
Antineoplastic/Anticancer
Methotroxate
Busulfan
Anti-inflammatory
Salicylates/Aspirin
Acetaminophen
Neuroleptics
Risperdal
Olonszapine
Quetapine
Asopiprazole
Reference method for TDM
GC-MS
what must be avoided in sample collection for TDM specimen
Serum Separator Tube (Nixothropic gel)
single most important factor in TDM
Timing of specimen collection
Through concentration
blood must be collected 30 mins/immediately before next dose
