Therapeutic Antibodies Flashcards
Therapeutic Antibodies
Alemtuzumab
Target: CD52
Use: CLL, MS
Therapeutic Antibodies
Bevacizumab
Target: VEGF
Use: Colorectal cancer, renal cell carcinoma
Therapeutic Antibodies
Cetuximab
Target: EGFR
Use: Stage IV colorectal cancer, head & neck cancer
Therapeutic Antibodies
Rituximab
Target: CD20
Use: B-cell non-Hodgkin lymphoma, CLL, rheumatoid arthritis, ITP
Therapeutic Antibodies
Trastuzumab
Target: HER2/neu
Use: Breast cancer
Therapeutic Antibodies
Adalimumab, certolizumab, infliximab
Target: Soluble TNF-α
Use: IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis
Therapeutic Antibodies
Eculizumab
Target: Complement protein C5
Use: Paroxysmal nocturnal hemoglobinuria
Therapeutic Antibodies
Natalizumab
Target: α4-integrin
Use: Multiple sclerosis, Crohn disease
Therapeutic Antibodies
Abciximab
Target: Platelet glycoproteins IIb/IIIa
Use: Antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous intervention
Therapeutic Antibodies
Denosumab
Target: RANKL
Use: Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegerin)
Therapeutic Antibodies
Digoxin immune Fab
Target: Digoxin
Use: Antidote for digoxin toxicity
Therapeutic Antibodies
Omalizumab
Target: IgE
Use: Allergic ashtma; prevents IgE binding to FcεRI
Therapeutic Antibodies
Palivizumab
Target: RSV F protein
Use: RSV prophylaxis for high-risk infants
Therapeutic Antibodies
Ranibizumab, bevacizumab
Target: VEGF
Use: Neovascular age-related macular degeneration
