Drug Reactions

Question 1

Drug Reactions

Coronary vasospasm

Answer 1

Cocaine, sumatriptan, ergot alkaloids

Question 2

Drug Reactions

Cutaneous flushing

Answer 2

Vancomycin, adenosine, niacine, Ca2+ channel blockers, Echinocandins (VANCE)

Question 3

Drug Reactions

Dilated cardiomyopathy

Answer 3

Anthracyclines (e.g. doxorubicin, daunorubicin); prevent with dexrazoxane

Question 4

Drug Reactions

Torsades de pointes

Answer 4

Antiarrhythmics (class IA, III), antibiotics (eg. macrolides), antipsychotics (eg. haloperidol), antidepressants (eg. TCAs), antiemetics ( eg. ondansetron)

Question 5

Drug Reactions

Adrenocortical insufficiency

Answer 5

HPA suppression 2° to glucocorticoid withdrawal

Question 6

Drug Reactions

Hot flashes

Answer 6

Tamoxifen, clomiphene

Question 7

Drug Reactions

Hyperglycemia

Answer 7

Tacrolimus, protease inhibitors , niacin, HCTZ, coticosteroids

Question 8

Drug Reactions

Hypothyroidism

Answer 8

Lithium, amiodarone, sulfonamides

Question 9

Drug Reactions

Acute cholestatic hepatitis, jaundice

Answer 9

Erythromcyin

Question 10

Drug Reactions

Diarrhea

Answer 10

Acamprosate, acarbose, cholinsterase inhibitors, colchicine, erythromycin, ezetimibe, metformin, misoprostol, orlistat, pramlintide, quinidine, SSRIs

Question 11

Drug Reactions

Focal to massive hepatic necrosis

Answer 11

Halothane, amanita phalloides (death cap mushroom), valproic acid, acetaminophen

Question 12

Drug Reactions

Hepatitis

Answer 12

Rifampin, isoniazid, pyrazinamide, statins, fibrates

Question 13

Drug Reactions

Pancreatitis

Answer 13

Didanosine, corticosteroids, alcohol, valproic acid, acetaminophen

Question 14

Drug Reactions

Pill-induced esophagitis

Answer 14

Tetracyclines, bisphosphonates, potassium chloride

Question 15

Drug Reactions

Psuedomembranous colitis

Answer 15

Clindamycin, ampicillin, cephalosporin

Question 16

Drug Reactions

Agranulocytosis

Answer 16

Clozapine, carbamazepine, propylthiouracil, methimazole, colchicine, ganciclovir

Question 17

Drug Reactions

Aplastic anemia

Answer 17

Carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil

Question 18

Drug Reactions

Direct Coombs-⊕ hemolytic anemia

Answer 18

Methyldopa, penicillin

Question 19

Drug Reactions

Gray baby syndrome

Answer 19

Chloramphenicol

Question 20

Drug Reactions

Hemolysis in G6PD deficiency

Answer 20

Isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

Question 21

Drug Reactions

Megaloblastic anemia

Answer 21

Phenytoin, methotrexate, sulfa drugs

Question 22

Drug Reactions

Thrombocytopenia

Answer 22

Heparin

Question 23

Drug Reactions

Thrombotic complications

Answer 23

OCPs, hormone replacement therapy

Question 24

Drug Reactions

Fat redistribution

Answer 24

Protease inhibitors, glucocorticoids

Question 25

# Drug Reactions Gingival hyperplasia

Answer 25

Phenytoin, Ca2+ channel blockers, cyclosporine

Question 26

# Drug Reactions Hyperuricemia (gout)

Answer 26

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

Question 27

# Drug Reactions Myopathy

Answer 27

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-α, pencillamine, statins, glucocorticoids

Question 28

# Drug Reactions Osteoporosis

Answer 28

Corticosteroids, heparin

Question 29

# Drug Reactions Photosensitivity

Answer 29

Sulfonamides, amiodarone, tetracyclines, 5-FU

Question 30

# Drug Reactions Rash (Stevens-Johnson syndrome)

Answer 30

Anti-epileptic drugs (especially lamotrigine), allopurinol, sulfa drugs, penicillin

Question 31

# Drug Reactions SLE-like syndrome

Answer 31

Sulfa drugs, hydralazine, isoniazid, procainamide, phenytoin, etanercept

Question 32

# Drug Reactions Teeth discoloration

Answer 32

Tetracyclines

Question 33

# Drug Reactions Tendonitis, tendon rupture, and cartilage damage

Answer 33

Fluoroquinolones

Question 34

# Drug Reactions Cinchonism

Answer 34

Quinidine, quinine

Question 35

# Drug Reactions Parkinson-like syndrome

Answer 35

Antipsychotics, reserpine, metoclopramide

Question 36

# Drug Reactions Seizures

Answer 36

Isoniazid, bupropion, imipenem/cilastatin, tramadol, enflurane

Question 37

# Drug Reactions Tardive dyskinesia

Answer 37

Antipsychotics, metoclopramide

Question 38

# Drug Reactions Diabetes insipidus

Answer 38

Lithium, demeclocycline

Question 39

# Drug Reactions Fanconi syndrome

Answer 39

Tenofovir, ifosfamide

Question 40

# Drug Reactions Hemorrhagic cystitis

Answer 40

Cyclophosphamide, ifosfamide

Question 41

# Drug Reactions Interstitial nephritis

Answer 41

Methicillin, NSAIDs, furosemide

Question 42

# Drug Reactions SIADH

Answer 42

Carbamazepine, cyclophosphamide, SSRIs

Question 43

# Drug Reactions Dry cough

Answer 43

ACE inhibitors

Question 44

# Drug Reactions Pulmonary fibrosis

Answer 44

Methotrexate, nitrofurantoin, carmustine, bleomycin, busulfan, amiodarone

Question 45

# Drug Reactions Antimuscarinic

Answer 45

Atropine, TCAs, H1-blockers, antipsychotics

Question 46

# Drug Reactions Disulfiram-like reaction

Answer 46

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas

Question 47

# Drug Reactions Nephrotoxicity/ototoxicity

Answer 47

Aminoglycosides, vancomycin, loop diuretics, cisplatin

Question 48

# Drug Reactions Cytochrome P-450 inducers (CHRONIC ALCOHLics STeal Phen-Phen and NEver Refuse GReasy CARBs)

Answer 48

``` Chronic alcohol use St. John's wort Phenytoin Phenobarbitol Nevirapine Rifampin Griseofulvin Carbamazepine ```

Question 49

# Drug Reactions Cytochrome P-450 Substrates (AS TWO)

Answer 49

``` Anti-epileptics Statins Theophylline Warfarin OCPs ```

Question 50

# Drug Reactions Cytochrome P-450 Inhibitors (AAA RACKS IN GQ Magazine)

Answer 50

``` Acute alcohol abuse Ritonavir Amiodarone Cimetidine/ciprofloxacin Keotconazole Sulfonamides Isoniazid Grapefruit juice (furocoumarins) Quinidine Macrolides (except azithromycin) ```