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Pharmacology > Drug Reactions > Flashcards

Drug Reactions Flashcards

1
Q

Drug Reactions

Coronary vasospasm

A

Cocaine, sumatriptan, ergot alkaloids

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2
Q

Drug Reactions

Cutaneous flushing

A

Vancomycin, adenosine, niacine, Ca2+ channel blockers, Echinocandins (VANCE)

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3
Q

Drug Reactions

Dilated cardiomyopathy

A

Anthracyclines (e.g. doxorubicin, daunorubicin); prevent with dexrazoxane

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4
Q

Drug Reactions

Torsades de pointes

A

Antiarrhythmics (class IA, III), antibiotics (eg. macrolides), antipsychotics (eg. haloperidol), antidepressants (eg. TCAs), antiemetics ( eg. ondansetron)

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5
Q

Drug Reactions

Adrenocortical insufficiency

A

HPA suppression 2° to glucocorticoid withdrawal

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6
Q

Drug Reactions

Hot flashes

A

Tamoxifen, clomiphene

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7
Q

Drug Reactions

Hyperglycemia

A

Tacrolimus, protease inhibitors , niacin, HCTZ, coticosteroids

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8
Q

Drug Reactions

Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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9
Q

Drug Reactions

Acute cholestatic hepatitis, jaundice

A

Erythromcyin

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10
Q

Drug Reactions

Diarrhea

A

Acamprosate, acarbose, cholinsterase inhibitors, colchicine, erythromycin, ezetimibe, metformin, misoprostol, orlistat, pramlintide, quinidine, SSRIs

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11
Q

Drug Reactions

Focal to massive hepatic necrosis

A

Halothane, amanita phalloides (death cap mushroom), valproic acid, acetaminophen

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12
Q

Drug Reactions

Hepatitis

A

Rifampin, isoniazid, pyrazinamide, statins, fibrates

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13
Q

Drug Reactions

Pancreatitis

A

Didanosine, corticosteroids, alcohol, valproic acid, acetaminophen

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14
Q

Drug Reactions

Pill-induced esophagitis

A

Tetracyclines, bisphosphonates, potassium chloride

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15
Q

Drug Reactions

Psuedomembranous colitis

A

Clindamycin, ampicillin, cephalosporin

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16
Q

Drug Reactions

Agranulocytosis

A

Clozapine, carbamazepine, propylthiouracil, methimazole, colchicine, ganciclovir

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17
Q

Drug Reactions

Aplastic anemia

A

Carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil

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18
Q

Drug Reactions

Direct Coombs-⊕ hemolytic anemia

A

Methyldopa, penicillin

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19
Q

Drug Reactions

Gray baby syndrome

A

Chloramphenicol

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20
Q

Drug Reactions

Hemolysis in G6PD deficiency

A

Isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

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21
Q

Drug Reactions

Megaloblastic anemia

A

Phenytoin, methotrexate, sulfa drugs

22
Q

Drug Reactions

Thrombocytopenia

A

Heparin

23
Q

Drug Reactions

Thrombotic complications

A

OCPs, hormone replacement therapy

24
Q

Drug Reactions

Fat redistribution

A

Protease inhibitors, glucocorticoids

25
Q

Drug Reactions

Gingival hyperplasia

A

Phenytoin, Ca2+ channel blockers, cyclosporine

26
Q

Drug Reactions

Hyperuricemia (gout)

A

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

27
Q

Drug Reactions

Myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-α, pencillamine, statins, glucocorticoids

28
Q

Drug Reactions

Osteoporosis

A

Corticosteroids, heparin

29
Q

Drug Reactions

Photosensitivity

A

Sulfonamides, amiodarone, tetracyclines, 5-FU

30
Q

Drug Reactions

Rash (Stevens-Johnson syndrome)

A

Anti-epileptic drugs (especially lamotrigine), allopurinol, sulfa drugs, penicillin

31
Q

Drug Reactions

SLE-like syndrome

A

Sulfa drugs, hydralazine, isoniazid, procainamide, phenytoin, etanercept

32
Q

Drug Reactions

Teeth discoloration

A

Tetracyclines

33
Q

Drug Reactions

Tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinolones

34
Q

Drug Reactions

Cinchonism

A

Quinidine, quinine

35
Q

Drug Reactions

Parkinson-like syndrome

A

Antipsychotics, reserpine, metoclopramide

36
Q

Drug Reactions

Seizures

A

Isoniazid, bupropion, imipenem/cilastatin, tramadol, enflurane

37
Q

Drug Reactions

Tardive dyskinesia

A

Antipsychotics, metoclopramide

38
Q

Drug Reactions

Diabetes insipidus

A

Lithium, demeclocycline

39
Q

Drug Reactions

Fanconi syndrome

A

Tenofovir, ifosfamide

40
Q

Drug Reactions

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide

41
Q

Drug Reactions

Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

42
Q

Drug Reactions

SIADH

A

Carbamazepine, cyclophosphamide, SSRIs

43
Q

Drug Reactions

Dry cough

A

ACE inhibitors

44
Q

Drug Reactions

Pulmonary fibrosis

A

Methotrexate, nitrofurantoin, carmustine, bleomycin, busulfan, amiodarone

45
Q

Drug Reactions

Antimuscarinic

A

Atropine, TCAs, H1-blockers, antipsychotics

46
Q

Drug Reactions

Disulfiram-like reaction

A

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas

47
Q

Drug Reactions

Nephrotoxicity/ototoxicity

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

48
Q

Drug Reactions

Cytochrome P-450 inducers (CHRONIC ALCOHLics STeal Phen-Phen and NEver Refuse GReasy CARBs)

A 
Chronic alcohol use
St. John's wort
Phenytoin
Phenobarbitol
Nevirapine
Rifampin
Griseofulvin
Carbamazepine
49
Q

Drug Reactions

Cytochrome P-450 Substrates (AS TWO)

A 
Anti-epileptics
Statins
Theophylline
Warfarin
OCPs
50
Q

Drug Reactions

Cytochrome P-450 Inhibitors (AAA RACKS IN GQ Magazine)

A 
Acute alcohol abuse
Ritonavir
Amiodarone
Cimetidine/ciprofloxacin
Keotconazole
Sulfonamides
Isoniazid
Grapefruit juice (furocoumarins)
Quinidine
Macrolides (except azithromycin)

Pharmacology (17 decks)

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