Theories of Aging Flashcards
what is a loss of homeostasis
breakdown in maintenance of specific molecular structures and pathways
pleiotropy
single gene controls of influences multiple traits
antagonistic pleiotropic theroy
aging is an adaptive trait in which genes that can influence several traits are selected for and affect individual fitness in opposite ways at different stages of life
mitochondrial DNA damager
alters efficeiency of respiration/ATP production
more free radicals
what does telomere damage do
loss of activity and length
developmental genetic aging
results from genetically programmed induction
error catastrophey
cumulative errors in RNA and protein synthesis
what do free radicals damage
protein, lipid, DNA
accumulation
abnormal proteins are not remvoed
endocrine aging
levels of secretion of hormones change
immunologic aging
time acquried deficits in immune response and T cell function
nutritional model theory
lean mass as opposed to adipose tissue results in greater health and age
what are some diseases that can cause premature aging
down syndrome werner progeria klinefelter tuner myotonic dystrophy
cross linkage theroy
more cross linkages
results in altered molecules and altered function
damage accumulates - contributes to aging
clinker theory
potential harmful substances accumulate in body
substances interfere passively with body function
ex_ amyloid accumulate in heart and brain
