The Thyroid Gland Flashcards

1
Q

what does thyroid follicle consists of?

A

Stroma

Colloid

Follicular cells

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2
Q

what does thyroid gland produce?

A

Thyroxine (T4)

Tri-iodothyronine (T3)

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3
Q

what transport thyroid hormone?

A

Thyroxine binding globulin

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4
Q

Function of thyroid hormone

A
Growth
Cardiac output
Thermoregulation
Protein/carbohydrate metabolism
foetal development
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5
Q

What is hyperthyroidism

A

elevated concentration of T4 and T3, causing a suppression of TSH

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6
Q

What cause hyperthyroidism

A

Graves’ disease

Toxic multi-nodular goitre

Pituitary adenoma

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7
Q

What is graves’ disease

A

an autoimmune disease that causes overproduction of thyroid hormones

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8
Q

clinical finding in graves’ disease

A

rapid heart beat

palpable goitre

tremor

exophthalmos

fatigue

weight loss

heat intolerance

palpitations

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9
Q

what is a goitre

A

swelling of the thyroid gland

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10
Q

what is exophthalmos

A

bulging or protruding eyeball

causes immune cell infiltration and oedema

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11
Q

what could be the cause of exophthalmos

A

fibroblasts and epithelial cells around the eye have antigens similar to TSH receptor

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12
Q

what is toxic multi-nodular goitre

A

mutation in TSH receptor

formed thyroid follicles that are not under regulation

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13
Q

possible treatment for hyperthyroid

A

radiation
(iodine 131)

Drugs
anti-thyroid drug i.e. carbimazole, methimazole and propylthiouracil

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14
Q

what is hypothyroidism

A

decrease in circulation T3 and T4

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15
Q

cause of hypothyroidism

A

Hashimoto’s

dietary

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16
Q

what is Hashimoto’s diseases

A

an auto-immune disease

commonly seen in iodine-deficient diets

caused by circulating antibodies against thyroid peroxidase

17
Q

clinical findings of Hashimoto’s disease

A
fatigue
weight gain
pale
puffy face
feeling cold
joint and muscle pain
constipation
dry and thinning hair
18
Q

treatment of Hashimoto’s disease

A

hormone replacement

Levothyroxine

19
Q

what is the common symptoms when there is an iodine deficiency?

A

low IQ

short

non-verbal

non-responsive