The Thyroid Gland Flashcards
what does thyroid follicle consists of?
Stroma
Colloid
Follicular cells
what does thyroid gland produce?
Thyroxine (T4)
Tri-iodothyronine (T3)
what transport thyroid hormone?
Thyroxine binding globulin
Function of thyroid hormone
Growth Cardiac output Thermoregulation Protein/carbohydrate metabolism foetal development
What is hyperthyroidism
elevated concentration of T4 and T3, causing a suppression of TSH
What cause hyperthyroidism
Graves’ disease
Toxic multi-nodular goitre
Pituitary adenoma
What is graves’ disease
an autoimmune disease that causes overproduction of thyroid hormones
clinical finding in graves’ disease
rapid heart beat
palpable goitre
tremor
exophthalmos
fatigue
weight loss
heat intolerance
palpitations
what is a goitre
swelling of the thyroid gland
what is exophthalmos
bulging or protruding eyeball
causes immune cell infiltration and oedema
what could be the cause of exophthalmos
fibroblasts and epithelial cells around the eye have antigens similar to TSH receptor
what is toxic multi-nodular goitre
mutation in TSH receptor
formed thyroid follicles that are not under regulation
possible treatment for hyperthyroid
radiation
(iodine 131)
Drugs
anti-thyroid drug i.e. carbimazole, methimazole and propylthiouracil
what is hypothyroidism
decrease in circulation T3 and T4
cause of hypothyroidism
Hashimoto’s
dietary