Hepatic pathology Flashcards
what is liver failure
a deficiency in metabolic or synthetic capacity of the liver
which are the 2 liver failure
acute & chronic
what happen in the acute liver failure?
occurs due to rapid necrosis of hepatic tissue
what is acetaminophen
basically paracetamol
what do acetaminophen do?
inhibits COX enzymes in the brain
how does overdose works in paracetamol?
build up of N-acetyl-p-bnzoquinone imine which is a toxic substance
symptoms of acute liver failure
coagulopathy
encephalopathy
jaundice
what is hepatic encephalopathy
when toxins are build up in the blood stream from the damage liver, and they enters the brain and cause changes in the brain
how long can chronic liver failure progress of?
6 months
cause of chronic liver disease
alcoholism
viral hepatitis
haemochromatosis
Wilson’s disease
autoimmune disease
what does infection in hepatocytes result in
necrosis
what are the vaccine for the hepatitis?
hep B giving children in wales
hepA recommended for ppl travelling to high risk countries
HepC doesn’t have a vaccine
what are the clinical course for viral hepatitis
prodromal phase
2 weeks after exposure
iceteric phase
2-8 weeks post exposure
recovery phase
>8 weeks
symptoms occurs in chronic liver disease
nail clubbing anaemia caput medusae testicular atrophy spider nevi
symptoms that show a result of liver failure
jaundice
ascites
oedema
bruising