The Somatosensory System Flashcards

1
Q

What is the function of A alpha fibres?

A

To carry information from proprioceptors.

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2
Q

What is the function of A beta fibres?

A

To carry tactile information from mechanoreceptors of the skin.

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3
Q

What is the function of A delta fibres?

A

To carry pain and temperature information.

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4
Q

What is the function of C fibres?

A

To carry pain, temperature and itch information.

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5
Q

Define 2 point discrimination.

Why is this useful?

A
  • The minimum distance by which two stimuli must be separated to allow an individual to discriminate between them.
  • If two stimuli are within the same receptive field, they will be interpreted as one point of stimulation.
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6
Q

Define dermatome.

A

An area of skin innervated by afferent axon fibres from a single spinal nerve root.

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7
Q

Define adequate stimulus.

A

The property of a sensory receptor that determines the type of energy to which it will respond with the initiation of an action potential.

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8
Q

Which part of a neurone determines the adequate stimulus?

A

The nerve ending.

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9
Q

Which part of a neurone determines the signal threshold?

A

The nerve ending.

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10
Q

What is the function of slow adaptation and non-adaptation?

How does slow-adaptation and non-adaptation respond to unchanging stimuli?

Why is this useful?

A
  • Slow adaptation and non-adaptation function to detect the strength of a stimulus.
  • When the intensity of a stimulus stops changing , the frequency of action potentials generated by slow-adapting receptors decreases but very slowly. Non-adapting receptors do not change action potential frequency at all until the stimulus changes intensity again.
  • This is important for stimuli which an individual needs to stay aware of, for example pain or stretch (of skin).
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11
Q

What is the function of fast adaptation?

How does fast-adaptation respond to unchanging stimuli?

Why is this useful?

A
  • Fast adaptation functions to detect the rate of change of a stimulus.
  • When the intensity of a stimulus stops changing, the frequency of action potentials generated by fast-adapting receptors decreases quickly.
  • This is important for stimuli which an individual can stop paying attention to when the stimulus is no longer important, for example tactile (touch) receptors.
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12
Q

List the cutaneous sensory receptors.

List the stimuli to which each receptor responds.

A

1 - Mechanoreceptors (touch, pressure and vibration).

2 - Thermoreceptors (temperature).

3 - Nociceptors (noxious stimuli).

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13
Q

List the types of mechanoreceptors.

Which are located in the superficial layers of the skin?

Which are located in the deep layers of the skin?

A

Superficial layers:

1 - Meissner’s corpuscle.

2 - Merkel’s receptor.

Deep layers:

3 - Ruffini’s corpuscle.

4 - Pacinian corpuscle.

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14
Q

In which layer of the skin are Meissner’s corpuscles found?

A

In the papillary (superficial) dermis of glabrous skin.

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15
Q

List the stimuli to which Meissner’s corpuscles respond.

A

1 - Light touch.

2 - Vibration.

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16
Q

What type of adaptation do Meissner’s corpuscles exhibit?

What is the implication of this?

A
  • Fast adaptation.

- They require constantly changing stimuli.

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17
Q

Where are Merkel’s receptors found?

A
  • In high densities in the epidermis of the digits and around the mouth.
  • In low densities in other glabrous skin.
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18
Q

To which stimulus do Merkel’s receptors respond?

A

Light touch.

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19
Q

What type of adaptation do Merkel’s receptors exhibit?

A
  • Slow adaptation.

- They can sustain a constant light touch stimulus.

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20
Q

What apparatus forms Merkel’s receptors?

A

They are formed of specialised keratocytes, which are fibroblasts of the cornea.

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21
Q

Where are Ruffini’s corpuscles found?

A

In the papillary (superficial) dermis of glabrous skin.

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22
Q

List the stimuli to which Ruffini’s corpuscles respond.

A

1 - Lateral movement (stretching) of the skin.

2 - Deep touch.

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23
Q

What type of adaptation do Ruffini’s corpuscles exhibit?

A

Slow adaptation.

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24
Q

What apparatus forms Ruffini’s corpuscles?

A

Networks of collagen fibres.

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25
Q

Where are Pacinian corpuscles found?

A

In the reticular (deep) dermis of both glabrous and hairy skin.

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26
Q

List the stimuli to which Pacinian corpuscles respond.

A

Strong stimuli:

1 - Strong poking.

2 - Deep touch.

3 - High-frequency vibration (this is the primary stimulus).

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27
Q

What type of adaptation do Pacinian corpuscles exhibit?

A

Fast adaptation.

28
Q

What apparatus forms Pacinian corpuscles?

What is the function of this apparatus?

A
  • Nerve endings encapsulated in fluid-filled membranes.

- To absorb the force of mechanical stimuli.

29
Q

Where are hair follicle receptors found?

A

At the base of a hair follicle in the dermis.

30
Q

To which stimulus do hair follicle receptors respond?

A

Light touch (by deflection of the hair follicle).

31
Q

What type of adaptation do hair follicle receptors exhibit?

A

Fast adaptation.

32
Q

What apparatus forms hair follicle receptors?

A

They are just nerve fibres wrapped around the base of the hair follicle.

33
Q

What type of adaptation do cutaneous thermoreceptors exhibit?

A

Slow adaptation.

34
Q

List the two subcategories of cutaneous thermoreceptors.

A

1 - Thermoreceptors that respond to hot temperature.

2 - Thermoreceptors that respond to cold temperature.

35
Q

If cutaneous thermoreceptors exhibit slow adaptation, why are they poor indicators of absolute temperature and very sensitive to changes in temperature?

A

Because the sense of temperature comes from the comparison of the signals from hot and cold thermoreceptors.

36
Q

What apparatus forms cutaneous thermoreceptors?

A

They are just free nerve endings.

37
Q

To which family of ion channels do thermoreceptor ion channels belong?

Describe the nature of the ion channels that belong to this family.

What is the function of these ion channels?

A
  • The transient receptor potential family.
  • They are nonspecific cation channels (usually Na+).
  • These are the ion channels which cause cation influx in order to open the voltage gated channels that cause depolarisation (if the threshold is reached).
38
Q

What is the name of the ion channels that belong to cold cutaneous thermoreceptors?

When do these channels open?

A
  • TRPM8.

- These channels open between 10 and 38 degrees C.

39
Q

What is the name of the ion channels that belong to hot cutaneous thermoreceptors?

When do these channels open?

A
  • TRPV3 / 4.

- These channels open between 29 and 45 degrees C.

40
Q

What substance opens TRPM8 channels?

A

Menthol (this is why minty things give a cold sensation).

41
Q

Which fibres carry temperature information from cold cutaneous thermoreceptors?

Which fibres carry temperature information from hot cutaneous thermoreceptors?

A
  • Cold receptors send their action potentials via both C and A delta fibres.
  • Hot receptors send their action potentials via C fibres only.
42
Q

Why might high temperatures cause a paradoxical cold perception?

A

Because cold receptors are also excited by high temperatures starting at around 45 degrees C.

43
Q

To which stimuli do cutaneous nociceptors respond?

A

Any stimulus capable of damaging tissue.

44
Q

What type of adaptation fo cutaneous nociceptors exhibit?

A

Non-adaptation.

45
Q

What can be said about the threshold of cutaneous nociceptors?

A

It is relatively high.

46
Q

What apparatus forms cutaneous nociceptors?

A

They are just free nerve endings.

47
Q

List the two subcategories of cutaneous nociceptors.

A

1 - High threshold mechanoreceptors.

2 - Polymodal nociceptors.

48
Q

Which fibres carry temperature information from high threshold mechanoreceptors?

Which fibres carry temperature information from polymodal nociceptors?

A
  • High frequency mechanoreceptors send their action potentials via A delta fibres.
  • Polymodal nociceptors send their axons via C fibres.
49
Q

What is the difference between the sensation that arises from high threshold mechanoreceptors and polymodal nociceptors?

A
  • High threshold mechanoreceptors produce a well-localised pricking pain.
  • Polymodal nociceptors produce a poorly-localised burning pain.
50
Q

List the stimuli to which polymodal nociceptors respond.

A

1 - Mechanical stimulus.

2 - Damaging heat.

3 - Noxious chemicals.

51
Q

What is the name of the ion channels that belong to hot polymodal nociceptors?

A

TRPV1.

52
Q

Which substance opens TRPV1 channels?

A

Capsaicin.

53
Q

List the 2 sensory receptors that give rise to proprioceptive information.

A

1 - Muscle spindle / intrafusal fibres.

2 - Golgi tendon organs.

54
Q

List 5 properties of the musculoskeletal system that are conveyed in proprioception.

A

1 - Joint position.

2 - Muscle length.

3 - Muscle movement.

4 - Acceleration.

5 - Tension / force.

55
Q

What are muscle spindles / intrafusal fibres?

A

Specialised muscle fibres contained within a fibrous capsule.

56
Q

What type of A alpha fibres carry proprioceptive information from muscle spindle?

A

Type 1A afferents.

57
Q

What type of A alpha fibres carry proprioceptive information from golgi tendon organs?

A

Type 1B afferents.

58
Q

What are golgi tendon organs?

A

Encapsulated collagen fibres that are in series with muscle at the junction of the muscle and the tendon.

59
Q

To which stimulus does muscle spindle respond?

To which stimulus does golgi tendon organ?

A
  • Muscle spindle responds to stretch of muscle.

- Golgi tendon organs respond to tension at the junction of the muscle and tendon.

60
Q

List the 2 main sensory pathways.

In which areas of the spinal cord do these pathways ascend?

A

1 - Lemniscal pathway (dorsal columns).

2 - Spinothalamic pathway (anterolateral tracts).

61
Q

List the stimuli that excite fibres in the lemniscal pathway.

A

1 - Touch.

2 - VIbration.

3 - Proprioception.

62
Q

List the stimuli that excite fibres in the spinothalamic pathway.

A

1 - Pain.

2 - Temperature.

63
Q

Which pathway is responsible for two-point discrimination?

A

The lemniscal pathway.

64
Q

List the fibres that ascend the spinothalamic pathway.

A

1 - A delta fibres.

2 - C fibres.

65
Q

Which fibre type ascends the lemniscal pathway?

A

A beta fibres.