The Skeletal System Flashcards
List the typical features of a long bone?
- Diaphysis
- Epiphysis
- Metaphysis / epiphyseal plate
- Articular Cartilage
- Periosteum
- Medullary Cavity
- Endosteum
What is the diaphysis of a long bone?
Shaft/long main portion of a bone
What is the epiphysis of a long bone?
Distal and proximal extremities or ends of the bone
What is the metaphysis of a long bone?
Region in a mature bone where diaphysis joins the epiphysis
In a growing bone it includes the epiphyseal plate where cartilage is replaced by bone.
What is the epiphyseal plate?
Layer of hyaline cartilage that allows the diaphysis of the bone to grow in length.
What is articular cartilage?
Thin layer of hyaline cartilage covering the epiphysis where the bone forms an articulation (joint) with another bone.
Cartilage reduces friction and absorbs shock at freely moveable joints.
What is the periosteum?
The membrane around the surface of the bone not covered by articular cartilage.
Two layers – outer fibrous layer (dense, irregular connective tissue contain blood vessels lymphatic vessels and nerves that pass into the bone), inner osteogenic layer contains elastic fibres, blood vessels and bone cells.
Periosteum is essential for bone growth in diameter, repair and nutrition, also serves as a point of attachment for ligaments and tendons.
What is the medullary (marrow) cavity?
The space within the diaphysis that contains the fatty yellow bone marrow in adults.
What is the endosteum?
Lining the medullary cavity is the endosteum, a membrane that contains osteoprogenitor cells and osteoclasts.
What is ossification?
Process whereby existing connective tissue is replaced by bone
What are the two methods of ossification?
- Intramembranous eg.
▪Bones of the skull
▪Bone formation occurs within loose fibrous connective tissue membranes
- Endochondral eg.
▪Long bones
▪Bone formation occurs within hyaline model
▪Most common method of ossification
When does ossification start?
Ossification begins 6th or 7th week of embryonic life and continues throughout adulthood.
What is intramembranous ossification simply?
Formation of bone directly on or within loose fibrous connective tissue membranes- eventually replaced by bone through intramembranous ossification.
What is endochondral ossification simply?
Formation of bone in hyaline cartilage, -mesenchyme is transformed into chondroblasts (responsible for cartilage formation)– produce a hyaline matrix that is gradually replaced by bone.
What intramembranous ossification has occurred on the left but not the right?
The fontanel has ossified and formed the sagittal suture
What is the benefit of a baby having a fontanel?
Membrane between bones – enables baby to pass along the birth canal, skull is incompletely ossified
When does the capitate start to ossify?
3 months
Explain the first step of intramembranous ossification?
- Development of the ossification centre: At the site where the bone will develop specific chemical messages cause the cells of the mesenchyme to cluster together and differentiate, first into osteo progenitor cells is then into osteoblasts. The sight of such a cluster is call and ossification centre. Osteoblasts secretes the organic extracellular matrix of bone until they are surrounded by it.
Explain the second step of intramembranous ossification?
- Calcification: the secretion of extracellular matrix stops, in the cells, now called osteocytes, lie in lacunae and extend their narrow cytoplasmic processes into canaliculi that radiates in all directions. Within a few days, calcium and other mineral salts are deposited and the extracellular matrix hardens or calcifies (calcification).
Explained the third step of intramembranous ossification?
- Formation of trabeculae: as the bone extracellular matrix forms it develops into trabeculae but use with one another to form spongy bone around network of blood vessels in the tissue. Connective tissue associated with the blood vessels in the trabeculae differentiates into red bone marrow.
Explain the fourth step of intramembranous ossification?
- Development of the periosteum: in conjunction with the formation of trabeculae, the mesenchyme condenses at the periphery of the bone and develops into the periosteum. Eventually a thin layer of compact bone replaces the surface layers of the spongy bone but spongy bone remains in the centre. Much of the newly formed bone is remodelled (destroyed and reformed) as the bone is transformed into its adult size and shape.
When does the hamate start to ossify?
2 months
When does the triquetrum start to ossify?
3 years
When does the lunate start to ossify?
4 years
When does the trapezium start to ossify?
4-5 years
When does the trapezoid start to ossify?
4-5 years
When does the scaphoid start to ossify?
4-5 years
When does the pisiform start to ossify?
8-12 years