The Phisiology Of Skeletal Muscle Flashcards
The Sliding Filament Theory
1- Preparing Binding Site
- action potential allows for the sarcoplasm in reticulum to release calcium ions
- ions bind to troponin in which pulls tropomyosin exposing the myosin
2- The Power Stroke
- cross bridge created
- when binded to myosin head it pulls the actin filament towards sarcomere centre
3- The Binding Site
- ATP re energises the myosin head
- myosin filament uncouple from the actin filament
4) The Ratchet Mechanism
- sufficient calcium is needed
- myofibril gets smaller
- h zone disappears
5) Return Of Calcium
- calcium ions return to sarcoplasmic reticulum
- troponin shape changes
Actin
- the thin protein filament sound in the muscle cells that together with myosin form sarcomeres, the contrachle units of the skeletal muscle
Myosin
- the thick protein filament that together with actin form sarcomeres the contractile units of the skeletal muscle
Troponin
- a calcium receptor that sits on the top of troponin
Tropomyosin
- spirals that wrap around the actin filament which covers the myosin binding site which prevents myosin attachment during relaxed state
The structure of the skeletal muscle
- the muscle belly is wrapped in a thick tissue that allows for movement of muscles and carries the epimysium
- perimysium surrounds bundles of muscle fibres named fasciculi
- endomysium surrounds each individual fibre
- each of them extend to form tendons
- muscle fibres are made of of hundreds of myofibrils
- these contain actin and myosin which allow for energy production and the control of the movement
SFT- Step 1- preparing the binding site
- troponin pulls tropomyosin away form the binding site
- sarcoplasmic reticulum releases calcium ions
- troponin and tropomyosin are found on the actin filament
SFT- Step 2- Power Stroke
- myosin head attaches to actin filament
- myosin head pulls the actin filament towards the centre of the sarcomere
- myosin head is thick
- actin filament is thin
SFT- Step 3- binding ATP
- ATP releases energy
- energy allows the myosin to pull the actin filament inwards and so shortening the muscle
- how is the ATP binding site exposed for re energising? Myosin filament uncoupled from actin filament allowing ATP to bind onto it- returning the myosin back to re energising state
- H zone gets smaller as the muscle contracts
STF- Step 4- ratchet mechanism
- myosin detaches from the actin
- sarcomere length gets smaller as well as the the myofibril
- sarcoplasmic reticulum keeps releasing calcium ions and the H zone eventually disappears
SFT- Step 5- return of calcium
- calcium leave the myosin binding site as their is no actin potential
- calcium ions go to the sarcoplasmic reticulum
- muscles become relaxed
Slow Twitch Muscle Fibres (type 1)
- they contract more slowly but are highly resistant to fatigue
- favoured by endurance athletes
Fast Twitch Muscles Fibres (type 2)
- they contract more rapidly generating greater forces but are more liable to fatigue
- favoured by sprinters and power athletes
The 2 types
1) type 2b- fast oxidative glycolytic- they are more resistant to fatigue
2) type 2b- fast twitch glycolytic- greater anaerobic capacity
Slow Twitch characteristics
Speed of contraction- slow
Force of contraction- low
Resistance to fatigue- very high
Aerobic capacity- very high
Anaerobic capacity- low
Fibre size- small
Mitochondrial density- high
Capillary density- high
Myoglobin content- high
PC store- low
Glycogen store- low
Triglyceride store- high
Fast twitch- type 2a characteristics
Speed of contraction- fast
Force of contraction- high
Resistance to fatigue- moderate
Aerobic capacity- moderate
Anaerobic capacity- high
Fibre size- large
Mitochondrial density- moderate
Capillary density- moderate
Myoglobin content- moderate
PC store- high
Glycogen store- high
Triglyceride store- moderate
Fast twitch- type 2b characteristics
Speed of contraction- fast
Force of contraction- highest
Resistance to fatigue- low
Aerobic capacity- low
Anaerobic capacity- high
Fibre size- large
Mitochondrial density- low
Capillary density- low
Myoglobin content- low
PC store- high
Glycogen store- high
Triglyceride store- low
Muscle fibre recruitment
- each muscle fibre within the muscle belly is supplied by only one motor neuron but can innervate anything from just a few fibres into several hundred
Motor Unit
- it’s a basic functional unit of skeletal muscle
- it is the motor nerve and group of muscle fibres it controls
- stimulation of one motor neurone causes all the muscle fibres in that motor unit to contract simultaneously
- each individual muscle will be made up of motor units
- the amount of motor units recruited depends on the amount of strength required for a given movement
- greater strength= more motor units
- motor units are usually made up of the same muscle fibre type