The Itis

Question 1

TINU

Answer 1

HLA DRB 1 012

Young women
Bilateral
Non granulomatous , anterior

Diagnosis:
Abnormal Cr
Increased b2 microglobulin in urine
Systemic symptoms

Question 2

Birdshot

Answer 2

HLA A 29

Question 3

Reactive Arthritis

Answer 3

HLA B27

Ureaplasma , Chlamydia, Shigella, Salmonella, Yersinia

Palms soles and penis

Question 4

Acute anterior uveitis

Answer 4

HLA B27

Question 5

JIA

Answer 5

HLA A2, DR5, DR8, DR11, DP2

Stills: under 5 yrs, fever rash
Polyarticular: 4 joints in first 6 months ; + RF false
Oligoarticular: most with uveitis, 1 - young girls with positive ANA, 2- older boys HLAB27

Acrylic lens only

Question 6

Bechets

Answer 6

HLA B51

Question 7

Intermediate Uveitis

Answer 7

HLA B8, B51, DR2, DR15

Question 8

Sympathetic Ophthalmia

VKH

Answer 8

HLA DR4

Question 9

Sarcoidosis

Answer 9

HLA B8

HLA B13

Question 10

Multiple Sclerosis

Answer 10

HLA B7, DR2

Question 11

Retinal Vasculitis

Answer 11

HLA B44

Question 12

Uveitis with Retinal Arteritis

Answer 12

SLE
PAN
Syphilis
HSV
VZV
IRVAN 
Churg Strauss

Question 13

Uveitis with Retinal Phlebitis

Answer 13

Sarcoidosis 
MS
Bechet
Birdshot
HIV
Eales

Question 14

Uveitis with Arteritis and Phelbitis

Answer 14

Toxo
Relapsing polychondritis
GPA
Crohn
Frosted branch Nagori’s

Question 15

Azathioprine

Answer 15

Purine nucleoside analog
Treat: Bechets, intermediate uveitis, VKH, SO, necrotizing scleritis. Start at 50mg/ day for a week.
Test for TPMT , if low don’t treat

Question 16

Methotrexate

Answer 16

Folic acid inhibitor of dihydrofolate reductase ; anti inflammatory effect from extracellular release of adenosine

Treat: JIA, sarcoidosis, panuveitis, scleritis

10-15 mg per week

Question 17

Mycophenolate mofetil

Answer 17

Inhibits inosine monophosphate dehydrogenase

Treat: kids

1-1.5 g BID

Question 18

Cyclosporine

Answer 18

Calcineurin inhibitors that eliminate T cell receptor signal transduction and downregulate IL

Side effects : HTN and nephrotoxicity , increased Cr

Treat: bechets, VKH, posterior

Question 19

Tacrolimus

Answer 19

Calcineurin inhibitor downregulates IL2

Nephrotoxic

Question 20

Cyclophosphamide , Chlorambucil

Answer 20

Alkylating agent
Necrotizing scleritis associated with GPA, relapsing polychondritis , intermediate, VKH, SO, Bechets

Cyclophosphamide - hemorrhagic cystitis
Chlorambucil - monitor CBC
Can result in sterility !

Question 21

Biologics

Answer 21

Inhibit cytokines

Etanercept: TNF receptor blocker - JIA

Infliximab; IgG against TNFa - Bechet, VKH, SO

Adalimumab: IgG against TNfa -

Question 22

Drug Induced Uveitis

Answer 22

Rifabutin 
Moxifloxacin
Bisphosphonates
Sulfonamides
Diethylcarbamazine
OCP
Etanercept
Metipranol
Anticholinesterase inhibitors 
Prostaglandin F2 analogues

Question 23

Goldmann Witmer equation

Answer 23

IgG in aqueous/ total IgG in aqueous
——————————————
IgG in serum / Total IgG in serum

> 3 indicates local antibody production

Question 24

Sarcoid related conditions

Answer 24

Lofgrens: hilar lymphadenopathy, anterior Uveitis

mikulicz : lacrimal and parotid swelling and sicca

Heerfordt: fever, parotid enlargement, anterior Uveitis, facial nerve palsy