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Clinical Chemistry 2 > The Gonadal Hormones > Flashcards

The Gonadal Hormones Flashcards

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1
Q

Test principles used in steroid hormone analysis

A

Colorimetric method

Both test for steroid hormone analysis uses colorimetric (17-KS.and Urin

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2
Q

Zimmerman Reaction in Urine 17-Ketosteroids (17-KS)

what is the color reaction in Zimmerman reaction?

17-KS when treated with metadinitrobenzene in alcohol alkali produces a

A

Red-purple

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3
Q

Urine 17-Hydrocorticosteroids

What are the 2 methods used to test for Urine 17-Hydrocorticosteroids

please observe the proper use of capitalization of letters and punctuation marks, as needed.

A

Porter-Silber Method and Zimmerman procedure

Estimates 11-deooxycortisol, Cortisol, Cortisone in urine.

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4
Q

Porter Silber Method

what is the color reaction in Porter-Silber Method?

Reagent: 2,4-dinitrophenylhydrazine and H2SO4

A

yellow

measured at 410nm

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5
Q

Zimmerman procedure/reaction in Urine 17-Hydrocorticosteroids

Aside from 11-deoxycortisol, Cortisol, Cortisone; what other reagents are used in Zimmerman procedure?

A

17-hydroxyprogesterone and 17-hydroxypregnenolone

thesea re used to determine pregnanetriol and metabolites.

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6
Q

Gonadal Hormones diseases

Pathophysiology: Abnormal balance of androgen hormones in women, causing excessive hair growths in areas like moutha and chin.

A

Hirsutism

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7
Q

Gonadal Hormones

Primary male growth hormone, which stimulates the production of male gonads

A

Androgen

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8
Q

Androgen

What are the 2 main androgens?

A

testosterone and androstenedione

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9
Q

Genital ducts

As androgen stimulates the developing genital ducts, it produces which duct?

mention both the present name and it’s (former name) inside parenthesis

follow proper letter capitalization; for special characters, just use the normal letters)

A

mesonephric (Wolffian ducts)

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10
Q

Genital ducts

Without any androgen stimulation the developing genital ducts develops into which duct?

mention both the present name and it’s (former name) inside parenthesis

follow proper letter capitalization; for special characters, just use the normal letters)

A

paramesonephric (Mullerian ducts)

No androgen stimulation results in forming female geitalia by default.

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11
Q

Gonadal Hormones Diseases

Pathophysiology: Hyperandrogenism, ovulatory dysfunction, aberrant relaeasing of GnRH, insulin resistance which may cause infertility, hirstutism, chronic anovulation, glucose intolerance, hyperlipidemia, hypertension, weight gain

A

Polycystic Ovary Syndrome (PCOS)

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12
Q

Gonadal hormones

2 pituitary hormones which controls testosteron secretion

answer using short term

A

FSH and LH

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13
Q

Gonadal hormones

which cells in pituitary gland prodces FSH and LH?

A

gonadotrophs

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14
Q

Organs

which organ produceh GnRH hormone?

A

Hypothalamus

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15
Q

Gonadal hormones

on which cells does FSH primarily acts upon?

A

germinal stem cells

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16
Q

gonadal hormones

on which cells does LH primarily acts upon?

please observe the proper capitalization of letters for proper nouns.

A

Leydig cells

17
Q

In PCOS investigation one test that is used is free testosterone.

what protein attaches to the active form of testosterone that is measured in the said test?

A

albumin

18
Q

Testosterone follows a circadian fashion

what is the peak time of testosterone production

A

8am

19
Q

Testosterone follows a circadian fashion

what is the lowest time of testosterone production

A

12am-4am

20
Q

PCOS investigation lab results:

What is the expected lab result for PCOS patients:
1. Free testosterone
2. SHBG
3. FSH
4. LH
5. FBG
6. Insulin
7. Lipid levels

A
  1. increase
  2. decrease
  3. increase
  4. increase
  5. increase
  6. increase
  7. increase
21
Q

hormones

this globulin binds testosterone and estrogen

A

Sex hormone bindign globulin

21
Q

hormones

most potent form of estrogen, which assists in FSH and LH regulation to develop endometrium with progesterone

short name (full name)

A

E2 (Estradiol)

22
Q

hormone

Major estrogen produced during pregnancy

A

E3 (Estriol)

23
Q

hormone

which form of estrogen is an indicator of ovarian function

short name

A

E2

24
Q

hormones

peak time of FSH and LH release

A

mid gestation

25
Q
A
26
Q

hormone

FSH and LH levels at birth

A

low

27
Q
A
27
Q

Gonadal hormone disease

common cause of secondary Amenorrhea

A

Clinical Chemistry 2 (4 decks)

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