The Female Reproductive System Flashcards
Gametes are produced in the….
ovaries
Fertilization takes place in the….
oviduct
Implantation takes place in the…
Uterus
_ is critical
Hormonal control
The pituitary gland receives signals from the…
CNS
FSH
Stimulates follicular development in the ovary and spermatogenesis in the testis
Secreted by basophils
LH
Regulates ovulation and corpus luteum formation
Stimulates steroid secretion by follicle and corpus luteum
Oocyte release results from…
Increased V/P follicular fluid
Plasmin proteolysis of follicular wall
GAGs deposition
Smooth muscle contraction in theca externa
Corpus Hemorrhagicum
Follicle walls collapse
Follicle lumen fills with blood from ruptured capillaries in the theca
Corpus Luteum
Follicle walls fold
Blood is re-absorbed/digested
Granulosa cells and theca interna cells luteinize
Will support pregnancy if implantation occurs
Corpus Albicans
No implantation
Granulosa and theca cells die
Replaced with collagen
_ is the most active form of estrogen
Estradiol
Production of estradiol requires activity from…
Both Theca Lutein Cells (TLC) ad Granulosa Lutein Cells (GLC)
What is detected by most pregnancy tests?
human Chorionic Gonadotropin (hCG)
What occurs during implantation?
Uterus halted in secretory phase
Placenta produces hCG
hCG will support Corpus luteum for 4-5 months
_ follicle (s) is/are usually supported to ovulation
Only one
What happens to the follicles that do not ovulate?
They undergo atresia
What does an atretic follicle look like?
Apoptotic cell death
ZP often is seen as remnant (ZP but no cell)
Fimbria
Finger like projections of the oviduct
How does the oocyte get to the uterus?
The fimbra from the oviduct bind to the corona radiata
Ciliated cells move it into the oviduct
How long is the oocyte viable?
24 hours
What are the two cell types found in the oviduct?
- ciliated cell
- Nonciliated secretory cell (Peg Cell)
Simple Columnar Epithelium
What is the difference between the oviduct and the seminal vesicle?
Oviduct - simple columnar ciliated epithelium with Peg Cells
Seminal Vesicles - Pseudostratified columnar epithelium w/no peg cells or apical modifications - may see lipofusion
T/F: Implantation is immediate
False
What are the three layers of the uterine wall?
Inner: Endometrium
Middle: Myometrium
Outer: Perimetrium
Endometrium
Simple columnar epithelium
Uterine Glands
CT with blood vessels
Myometrium
Smooth muscle
Stratum Vascularis
Perimetrium
Serosa OR
Visceral Periotenum
Pregnancy halts the uterine cycle in the…
Secretory phase
_ act on the uterus
Ovarian hormones
Hormone produced by follicle prior to ovulation
Estrogen
Estrogen stimulates…
Proliferative phase
Hormone produced by corpus luteum
Progesterone
Progesterone stimulates…
secretory phase
What are the three phases of the uterine endometrium cycle?
Proliferative
Secretory
Menstrual
Which phase has an increased stratum functionale?
Proliferative
Which phase has increased gland length/sawtooth glands?
Secretory
What phase has reduced stratum functionale?
Menstrual
Menstrual
Sloughing of functionalis layer of endometrium
Decrease in hormones induces growth factor withdrawal cell death
Hemorrhage due to destruction of spiral arteries
Proliferative
Functionalis layer thickens
Secretory
Functionalis reaches full thickeness
Helical arteries and uterine glands of the functionalis become highly coiled and lengthen
sawtooth appearance
Hormones involved in Menstrual Cycle
Reduced levels of estrogens and progesterone
Hormones involved in Proliferative phase
Increased blood levels of follicle-stimulating hormone (FSH) and estrogen
At the end of the proliferative phase, estrogen, FSH and LH blood levels peak
Hormones involved in secretory phase
Estrogen levels rise in the blood and progesterone blood levels peak
FSH and LH blood levels are decreased
_ artieres are found in the endometrium. What is their function?
Spiral (or helical)
Branched to provide nutrients to both layers
What is the function of the spiral shape of uterine vasculature?
Spiral shape increases blood volume to provide additional nutrients and fluid for glands
T/F: The stratum basale does not change substantially in the proliferative phase
True
T/F: The Menstrual cycle will always occur.
False
Which layer(s) are lost during the menstrual cycle?
Only the Stratum functionale
Hormone withdrawal causes…
Necrosis
Dilation of arteries and glands
Sloughing off of Stratum Functionale
What kind of epithelium is found in the vagina?
Stratified squamous nonkeratinized epithelium
Transformation zone
Shifts over the person’s lifetime
Shifts from SCE and SSE
Where is the transformation zone during prepubescence?
Outside the external os
Where is the transformation zone during reproductive years?
in the canal
Where is the transformation zone during Postmenopause?
Outside the external os
Glands in the cervix produce…
mucus to protect tissue
Nabothian cysts
Dilated glands in the cervix
Cells in the vaginal wall are filled with…
Glycogen
Describe the vaginal wall
SSE is nonkeratinized
Cells are filled with glycogen
Lamina propria interdigitates with epithelium
Muscle is smooth and not well organized
No glands
What is the purpose of the interdigiation of the lamina propria and epithelium of the vaginal wall?
Increases resistance to abrasion
Placenta
Allows for blood exchange between mother and fetus
Placenta Structure - rewatch video i like missed this all
Nipple
Areola has substantial sebaceous glands
Smooth muscle in CT forms circular sphincter
Lactieous ducts drain…
mammary gland lobes
What epithelium lines Lactiferous ducts?
Simple cuboidal/columnar epithelium
Myoepithelial cells
Breast tissue in non-lactating women
Ducts are present
There is virtually no secretory portion
Most tissue is dense CT and adipose tissue
How does the breast change during pregnancy?
Inactive: Adipose tissue, lactiferous duct system, lactiferous sinus, opening of sinus
Lactating breast: Adipose tissue, enlarged secretory lobules, elaborate duct system, myoepithelial cells, basal lamina, alveolar cell, milk lipids
Hormones secreted during pregnancy
Estrogen and progesterone
Prolactin (pituitary)
Gonadocorticoids (adrenal cortex)
When does milk release begin?
After Progesterone levels drop after birth
What are the two parts of secretion during lactation? What methods are they secreted by?
Milk fats (apocrine secretion)
Milk Proteins (Merocrine secretion)