The Endocrine System (ch18) Flashcards
what are the physiological signals
electrical signals and chemical signals
electrical signals
changes in the membrane potential of a cell
chemical signals
- molecules secreted by cells into extracellular fluid
- reponsible for most communication within the body
- chemical signals act as ligands that bind to proteins to initiate a response
molecules in nervous system
neurotransmitters released locally in response to nerve impulses
molecules in endocrine system
hormones delivered to tissue throughout body by blood
site of action for nervous system
close to site of release, at synapse; binds to receptors in postsynaptic membrane
site of action for endocrine system
- far from site of release (usually); binds to receptors on or in target cells
types of target cells in nervous system
- muscle cells, gland cells, other neurons
types of target cells in endocrine system
- cells throughout body
duration of action in nervous system
generally briefer
duration of action in endocrine system
generally longer
exocrine glands
secrete their products into ducts to be excreted to external environment
endocrine glands
do not have ducts, secret hormones
receptors are constantly being _____ and ______
synthesized and broken down
down regulation makes cells
less receptive
up-regulation makes cells more receptive
up-regulation makes cells more receptive
lipid soluble hormones
steroid hormones, thyroid hormones, nitric oxide
water soluble hormones
amine hormones, peptide hormones, eicosanoid hormones
steriod hormones
derived from cholesterol
thyroid hormones
although a protein, they behave like a lipid
nitric acid
gas produced by endothelial cells
amine hormones
decarboxylation of selected Amino Acids
peptide hormones
small to large proteins
eicosanoid hormones
- fatty acids that behave like proteins
- classified as autocrine/paracrine hormones
most water-soluble (hydrophilic) hormones circulate in _________
free form
what does preprohormone and prohormone refer to
inactive precursors
how often are peptide hormones release
- released in burst frequently throughout day.
mechanism of lipid-soluble hormones
- diffuse through the cell membrane
- bind to receptors in the cytosol or nucleus
cytoplasmic and nuclear receptors lead to what types of response
genomic response - which activate and represses gene transaction
thyroid hormones
- behaves like steroid hormone
T3 and T4 transported in blood by
- thyroid-binding globulin (TBG)
- transthyretin
- albumin
which hormones cannot cross the plasma membrane, so they must bind to the surface membrane receptors
- amine, peptide, protein