The Clinical Trial

Question 1

What is the appropriate type of lymph node biopsy used in suspected lymphoma?

Answer 1

Excisional lymph node biopsy

Question 2

What are the components of the Lugano classification for lymphoma?

Answer 2

1. Nodal disease
2. Extranodal disease
3. Bone marrow
4. Clinical parameters
5. Spleen/liver

Question 3

What is the standard scan used for assessing a lymphoma first line?

Answer 3

PET-CT to check for Hot areas

Question 4

When is a spleen deemed enlarged (splenomegaly) on CT scan?

Answer 4

> 13cm

Question 5

Define the following stage of lymphoma, according to the Lugano staging; Stage 1

Answer 5

Lymphoma is in a single lymph node or group of lymph nodes or in an organ of the lymphatic system (e.g. thymus)

Question 6

Define the following stage of lymphoma, according to the Lugano staging; Stage 1E

Answer 6

Lymphoma is in an extranodal site

Question 7

Define the following stage of lymphoma, according to the Lugano staging; Stage 2

Answer 7

Your lymphoma is in 2 or more groups of lymph nodes on the same side of the diaphragm

Question 8

Define the following stage of lymphoma, according to the Lugano staging; Stage 2E

Answer 8

Lymphoma is in an extranodal site and 1< groups of lymph nodes on the same side of the diaphragm

Question 9

Define the following stage of lymphoma, according to the Lugano staging; Stage 3

Answer 9

Lymphoma is present on both sides of the diaphragm (above and below)

Question 10

Define the following stage of lymphoma, according to the Lugano staging; Stage 4

Answer 10

Lymphoma is in an extranodal site and lymph nodes are affected
Lymphoma is in 1< extranodal sites e.g. liver, bone or lungs

Question 11

What are the b symptoms of lymphoma?

Answer 11

1. Night sweats
2. Fever
3. Unexplained weight loss
4. Fatigue
5. Appetite loss

Question 12

What is Good Clinical Practice (GCP) in relation to clinical trials?

Answer 12

A set of internationally recognised ethical and scientific quality requirements that must be followed when dealing with clinical trials that involve people.

Question 13

According to Common Terminology for Adverse Events (CTCAE), what does the following grade of toxicity mean; Grade 1?

Answer 13

Asymptomatic or mild

Question 14

According to Common Terminology for Adverse Events (CTCAE), what does the following grade of toxicity mean; grade 2?

Answer 14

Moderate and may impact instrumental ADL e.g. shopping, using the phone, cleaning

Question 15

According to Common Terminology for Adverse Events (CTCAE), what does the following grade of toxicity mean; grade 3?

Answer 15

Severe and affecting self care ADL

Question 16

According to Common Terminology for Adverse Events (CTCAE), what does the following grade of toxicity mean; Grade 4?

Answer 16

Life-threatening

Question 17

According to Common Terminology for Adverse Events (CTCAE), what does the following grade of toxicity mean; Grade 5?

Answer 17

Death

Question 18

How do NICE define the neutropenic sepsis categories of temperature and neutrophil count?

Answer 18

Temp >38

Neutrophil count <0.5x 10^9/L