The Cell Organelles Part 3 Flashcards
Which cytoplasmic organelles are membranous?
Mitochondria, Smooth&Rough endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, vesicles
Which cytoplasmic organelles are non-membranous?
Ribosomes, Centrioles, Cytoskeleton, Cilia, Flagella, Microvilli, Inclusions
Cytoskeleton
Has roles in cell movement, support and strength for the cell, phagocytosis, cytokinesis, cell-cell and cell-extracellular matrix adherence, and changes in cell shape
What is the cytoskeleton composed of?
The cytoskeleton is a complex network of microtubules, intermediate filaments, and microfilaments.
Microtubules
Composed of dimeric tubulin molecules and are structurally polarized with a plus end which in a low presence of a low Ca2+ concentration, guanosine triphosphate and Mg2+ grow more rapidly at the minus end
What are the three distinguishing factors of Alzheimer’s?
1) Accumulation of senile plaques B-amyloid accumulations
2) formation of numerous neurofibrillary tangles
3) Loss of cortical neurons particularly cholinergic neurons
Microtubular Functions
1) Intracellular vesicular transport
2) Movement of cilia & flagella
3) Attachment of chromosomes to the mitotic spindle
4) Cell elongation & movement
5) Maintenance of cell shape
Centrioles
Centrioles are cylindrical structures composed of short, highly organized microtubules. Centrosomes made of a pair of centrioles.
Cilia & Flagella
Cilia and flagella are motile processes covered by cell membrane with a highly organized microtubule core. The main function of cilia is to sweep fluid from the surface of cell sheets.
F-actin inhibitors
Cytochalasins- bind to fast growing end preventing further addition of G-actin. , Phalloidin- binds to actin filaments preventing depolymerization, Latrunculins- disrupt actin filaments by binding to G-actin an inducing F-actin deploymerization.
Intermediate Filaments
They provide mechanical support to cells. They lack polarity and do not require atp or gtp for synthesis.
Intermediate Filaments
The presence of a specific type of intermediate filament in tumors can reveal which cell originated the tumor information important for diagnosis and treatment.
Cytoplasmic deposits/ Inclusions
Usually transitory components of the cytoplasm, composed mainly accumulated metabolites or other substances.