The Biolgoics Flashcards
1
Q
What does this mean
cept
imab
zumab
A
cept = fusion protein
imab = chimeric (1/2 and 1/2 mouse
zumab = humanized
2
Q
Ipilimumab
A
CTLA
Metastatic melanoma
3
Q
Nivolumab
A
ligand activation of the PD-1 receptor.
Metastatic melanoma, Squamous non-small cel lung cancer
4
Q
Pembrolizumab
A
PD-1 receptor
Metastatic melanoma
NSCLC metastatic. at least 50% tumour cells positive.
5
Q
Alemtuzumab
A
B-cell CLL
target Cd53
6
Q
Omsimertinib
A
first line palliative treatment locally adv met NSCLC our are eGFR mut positive.
rash most common side effect.
EGFR TKI
works against T790M resistance muts
7
Q
Brigatinib
A
ALK positive NSCLC
ALK inhibiotor
8
Q
TKIs agaisnt BCR-ABL
A
Imatinib, Dasatinib, Nilotinib
9
Q
Targets of Sunitinib
A
VEGFR 1, VEGFR 2, PDGFR, KIT and RET
