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RACP 2022 Written > AutoAntibodies - From String of Pearls > Flashcards

AutoAntibodies - From String of Pearls Flashcards

1
Q

Anti-Ro (SSa)

A

Target: Ribonucleoproteins
Disease: SLE, Neonatal heart block + Primary Sjogrens syndrome

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2
Q

Anti-La (SS-B)

A

Against: Ribonucleoproteins
Disease: Primary Sjogrens

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3
Q

Anti-centromere Ab

A

Against: Centromere ANA pattern
Disease: CREST syndrome and limited Scleroderma

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4
Q

Anti- dsDNA

A

Against - double stranded DNA
Disease: SLE

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5
Q

Anti Jo1

A

Against - Histidine tRNA ligase
Disease: Inflam myopathy aka anti syntheses syndrome - polymyositis

mech hands. Anti-Jo + ILD = polymyositis

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6
Q

Anti-U1-RNP

A

Against: Ribonucleoprotein
Disease - Mixed Connective Tissue Disease

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7
Q

Anti- Smith

A

Target: snRNP core proteins
Disease: SLE (CNS lupus + Renal LUpus, African population , poor prognosis)

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8
Q

Anti- topoisomerase (anti-Scl70)

A

Target: Type 1 Topoisomerase
Disease: Systemic Sclerosis (diffuse)

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9
Q

Anti-histone

A

Taret: histones
SLE and drug induced lupus

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10
Q

Anti -CCP

A

Target: Cyclic citrullinated peptide
D: RA

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11
Q

Rheumatoid Factor

A

Target: IgG
D: RA

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12
Q

Anti-thrombin

A

Target: thrombin
D: SLE

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13
Q

c-ANCA (PR3)

A

T - Anti-proteins in neutrophil cytoplasm
D - GPA - Granulomatosis with polyangiitis aka wegners

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14
Q

p-ANCA (MPO)

A

T- anti-neutrophil perinuclear
D - MPA Microscopic polyangiitis, eGPA Eosinophilic granulomatosis with polyangiitis aka Churg-Strauss, Systemic vasculitides

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15
Q

Anti-SRP

A

T- Signal recogintion particle
D- Polymyositis (highly agressive form, poorly response immunosupression)

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16
Q

Anti-RNA polymerase III

A

T - RNA polymerase II
D - Renal crisis in systemic sclerosis

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17
Q

Anti-Ro52

A

second most common ab for systemic scleroderma fter anti-SCL70.
ILD and dermtomyositis

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18
Q

Anti-p155

A

Dermatomyositis subset - assoc with malignancy and more severe cutaneous involvement

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19
Q

Anti-HMGCR

A

T - HMG-CoA reductase
D - Statin induced necrotising myositis (immunosupress)

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20
Q

BAFF + IL-6

A

D - GCA, PMR

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21
Q

Anti-tTG

A

T - Transglutaminases
D - Coeliac disease

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22
Q

Anti-eTG

A

D - Dermatitis herpetiformis

Assoc with Coeliac Disease. Chronic, very itchy skin rash made up of bumps and blisters.
The exact cause of dermatitis herpetiformis isn’t known. Genetics, gluten sensitivity and disorders in which the immune system attacks healthy cells (auto-immune disorders) may play a role.
The main symptom is an off-and-on skin rash.
Antibiotics and a gluten-free diet are treatments.

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23
Q

Anti-Actin

A

Coeliac disease

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24
Q

Anti- LKM-1

A

D - Autoimmune hepatitis
most frequent young women and girls - poor prognosis

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25
Anti-SMA (smooth muscle)
T - Smooth muscle D - chronic autoimmune hepatitis
26
AMA (anti-mitochondrial antibody)
T - Mitochondria D - Primary billary cirrhosis
27
ASCA
T - Anti-Saccharomyces cerevisiae antibody D - Crohn's Disease (helps diff from UC - pANCA for UC)
28
Anti-ganglioside GQ1B
T - Ganglioside D - Miller Fisher Syndrome
29
Anti-ganglioside GD3
T- ganglioside D - Acute motor axonal neuropathy
30
Anti-ganglioside GM1
T- ganglioside D - Multifocal motor neuropathy with conduction block
31
Anti-AChR (Nicotinic acetylcholine receptor)
Disease - Myasthenia Gravis
32
Anti- MUSK *muscle specific kinase
Myasthenia gravis - not seen in ocular variant
33
Anti - LRP4 (lipoprotein receptor - related protein)
Myasthenia gravis (mild/mod)
34
Anit-VGCC - voltage gated calcium channel p/1 type
D - Lambert Eaton Myasthenic syndrome
35
Anti-Hu (ANNA-1)
T- Neuronal nuclear proteins D - SCLC, Neuroblastmoas, Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute senory neuronopathy, choreathetosis, myoclonus
36
Anti-Yo
T- Cerebellar Purkinje cells D - Ovarian and breast ca, paraneoplastic cerebellar degeneration
37
Anti-Ma
Encephalomyeleits, limbic encephalitis
38
ANti-RI (ANNA-2)
T - Neuronal nuclear proteins D - Opsoclonus myoclonus syndrome
39
Anti-Tr
T - GLuamate recpetor paraneoplasic cerebellar syndrome
40
Anti-amphiphysin
D - Stiff person syndrome, paraneoplastic cerebellar degeneration
41
Anti-GAD
T - Glutamate decarboxylase D - Breast, CRC, SCLC - stiff person syndrome
42
Anti- VGKC
T - Voltage - gated potassium channel (VGKC) D - Limbic encephalitis, Isaac's Syndrome (autoimmune neuromyotonia)
43
ANti-CRMP-5
T - Collapsin response mediator protein 5 D - Optic neuropathy, chorea
44
Anti-NMDAr
T - N-methyl-D-aspartate receptor (NMDA) D - Anti-NMDA receptor encephalitis
45
Anti-NMO
T - Aquaporin-4 D - Neuromyelitis optica
46
Anti-Cardiolipin
Antiphospholipid syndrome
47
Antiphospholipid syndrome
ANti-cardiolipin, Anti-beta-2-glycoprotein-1, Anti PF4
48
Anti-beta-2-glycoprotien 1
Antiphospholipid syndrome
49
Anti- PF 4
Heparin induced thrombocytopenia
50
Anti-TPO
T - Thyroid peroxidase (microsomal) D - Hashimoto's thyroiditis + Graves disease
51
Anti-TgAbs
T - Thyroglobuin D - Hashimoto's Thyroiditis
52
Anti-TRABs
T- TSH receptor D - Graves disease
53
Anti-GAD
T - Glutamate decarboxylase D - T1DM
54
Anti-PLA2R
T - Podocyte membrane antigen D - Membranous GN - 80% assoc primary - good response to rituximab
55
Anti-THSD7A
Membranous GN 2-5%
56
suPAR
T - Soluble urokinase type plasminogen activator receptor D- FSGS
57
Anti-GBM
T - alpha-3 subunit of type IV collagen D - Goodpasture's
58
C904G72 disease association?
FTD-MND
59
ALpha synuclein
Parkinsons, MSA, DLB
60
Tauopathies
Alzheimers, PSP, CBS, FTDP
61
TARDBP gene
FTD
62
Differentiating test Scleroderma?
+ anti-centromere Ab for limited scleroderma + anti-Scl 70 or anti-top for diffuse
63
Differentiating test Mixed connective tissue disease?
Positive anti-RNP Ab
64
Differentiating test Drug induced lupus?
Positive anti-histone ab
65
Differentiating test Adult Still's disease?
Elevated ferritin in a patient presenting with fever, rash and sero NEG polyarthritis
66
Differentiating test Septic arthritis?
Joint aspiration or synovial biopsy yields positive culture >50,000
67
Differentiating test Sjogren's syndrome?
Positive anti-Ro (heart block + lupus) and anti-La
68
Differentiating test SLE
Positive ANA (most sensitive) Anti-dsDNA and anti-Smith Ab (spec)
69
Differentiating test RA
Anti- CCP
70
Differentiating test Psoriatic arthritis
Pencil in cup deformity on XRAY (adv disease)
71
Differentiating test Gout?
Synovial fluid Ex - strong neg birefingent, needle shaped crystals under polarised light
72
Auto-Antibodie in ITP?
ANti-GLycoprotien IIB-IIa

RACP 2022 Written (21 decks)

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