The anterior eye Flashcards

1
Q

what are the tear film layers in order from outer to inner

A
  1. lipid layer
  2. aqueous layer
  3. aqueous phase (MUC 5AC)
  4. glycolax (MUC1), (MUC 4), (MUC 16)
  5. mucinous phase
  6. epithelial surface with microvilli
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2
Q

what can ocular surface and tear film disorders cause?

A

DED
MGD
CL DISCOMFORT

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3
Q

what are two types of dry eye disease? what are there symptoms?

A

dry eye syndrome (DES) and keratoconjunctivitis sicca (KCS)
-dryness
-discomfort
-irritation
-reduced vision

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4
Q

what are the two types of dry eye?

A

-aqueous deficiency where is affects the lacrimal gland function
-evaporative dry eye

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5
Q

what is the most frequent cause of DED?

A

MGD

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6
Q

why is it important to prevent DED

A

-it is very expensive to treat i.e.. cost of referrals, Px etc

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7
Q

what are the 4 inter-related mechanisms responsible for DED

A

-tear instability
-tear hyperosmolarity
-inflammation
-ocular surface damage

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8
Q

what is evaporative dry eye?

A

related to causes from
-lids such as MDG and blink problems
-ocular surface such as mucin or CL-related

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9
Q

what is another name for MGD

A

posterior blepharitis

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10
Q

how is obstructive MGD caused?

A
  1. terminal duct obstruction
  2. caused by hyperkeratinisation of the ductal epithelium, keratinised cell debris and increased meibum viscosity
  3. causes normal clear oily secretions to become semi-solid, toothpase like plaques
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11
Q

what kind of populations are most likely to have MGD?

A

mainly asian populations

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12
Q

what is the vicious cycle for dry eye disease?

A
  1. damage to ocular surface
  2. goblet cell loss
  3. mucin loss
  4. tear film instability
  5. excessive tear evaporation
  6. hyperosmolarity
    8.inflammation
  7. keratinisation of gland orfices
    which causes inflammation and the cycle repeats
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13
Q

what is the cycle for MGD?

A
  1. bacterial proliferation causes increased exotoxin release
  2. lipases and esterases destabilise the tear films lipid layer
  3. this causes a rise in meibum melting point
  4. which causes meibomian gland dysfunction
    which leads to proliferation of bacteria and the cycle repeats
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14
Q

What are the consistent risk factors for Dry eye?

A

-increasing age
-CL wear
-being female
-Asian ethnicity

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15
Q

what are the signs of dry eye?

A

-fluorescein staining, small tear meniscus height, TBUT <10

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16
Q

what are the symptoms of dry eye?

A

-discomfort
-dryness
-irritation
-grittiness
-fluctuating vision which may get worse throughout the day
-vision that gets worse with wind, smoke, heat and prolonged near activities

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17
Q

how do you diagnose dry eye?

A

-use the dry eye questionnaire to determine if they have symptoms of dry eye (difficult if time is limited)
-check tear film stability, tear film osmolarity or ocular surface staining
-check tear meniscus

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18
Q

how do you manage dry eye?

A

-dietary advice of eating more oily fish for omgea 3
-recommend ocular lubricants such as preservative free artificial tears
-wear protective glasses/ moisture chamber glasses
-use specialist care methods if these don’t work
-refer to secondary care if nothing else works

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19
Q

what specialist care methods can be used when treating dry eye?

A

-punctum plugs
-scleral / bandage contact lenses
-pharmacological management like topical steroids

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20
Q

what could be differential diagnoses to dry eye?

A

computer vision syndrome and digital eye strain

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21
Q

what are the risk factors for MGD?

A

-wearing CLs
-prolonged screen use (as it reduced blink rate)

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22
Q

what are the signs of MGD?

A

-changes to secretion of the gland
-saponification of tears
-gland plugging/ paste like yellowish secretion

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23
Q

diagnosis of MGD

A

-inspect the glands for the signs
-push on the meibomian glands to clear the blockage

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24
Q

MGD treatment?

A

squeeze the meibomian glands to clear the blockage

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25
Q

MGD management?

A
  1. use products to heat your eyes like heated eye mask
  2. massage the eyelids to clear the blockages
  3. clean the eyelids
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26
Q

in MGD when should you refer to secondary care?

A

-sometimes when you have peads px
-if they may have suspected underlying conditions or unidentified systemic diseases
-secondary complications like vascularisation, corneal scarring and infection
-abnormal lid anatomy/ function
-persistent/ severe Sx that dont want to respond to primary management after 4-12 weeks

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27
Q

Name two types of corneal inflammation

A

-marginal keratitis
-CL associated infiltrative events (CIE’S)

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28
Q

what is the aetiology of marginal keratitis?

A

an inflammatory response of the peripheral cornea to bacteria exotoxins instead of direct inocculation

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29
Q

what are the predisposing factors

A

-bacterial blepharitis
-sometimes contact lenses

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30
Q

what are the signs of marginal keratitis?

A

-redness and inflammation of limbus and bulbar conjunctiva due to excess blood in the vessels
- stromal infiltrate ( typically adjacent to the limbus and separated
by an interval of clear cornea)
-ulcers (they stain with fluorescein)

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31
Q

what are the symptoms of marginal keratitis

A

-ocular discomfort
-lacrimation
-red eye
-photophobia

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32
Q

what is the non pharmacological management of marginal keratitis?

A

-initially address predisposing factors e.g. contact lenses
-regular lid hygiene for associated blepharitis

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33
Q

what are the pharmacological managements for marginal keratitis?

A

-ocular lubricants for symptomatic relief
-systemic analgesia when needed (painkillers)
-topical antibiotic use to reduce bacterial load plus topical steroid to reduce inflammation

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34
Q

Name three CIEs

A

-contact lens-associated peripheral ulcer (CLPU)
-contact lens associated infiltrative keratitis
-contact lens associated acute red eye (CLARE)

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35
Q

what is the aetiology for CIEs?

A

a self limiting inflammatory response of the cornea affecting the anterior stroma

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36
Q

what are the patient related pre disposing factors of CIEs?

A

-blepharitis
-male sex
-being <25 years old
-smoking
-having previous Hx of CIEs

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37
Q

what are the predisposing factors of CIEs for patients who wear CLs?

A

-long term lens wear
-overnight wear
-silicon hydrogel material
-tight fit lens
-MSPs
-poor lens hygiene

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38
Q

what are the symptoms of CIEs?

A

-red and watery eye
-foreign body sensation
-photophobia
(some cases are even asymptomatic)

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39
Q

what are the signs of CIE’s?

A

-peripheral anterior stromal infiltrates, usually small
-ulcer formation
-conjunctival hyperaemia
-adjacent limbal hyperaemia
-epiphoria
-anterior chamber inflamed to some degree
-usually unilateral

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40
Q

Give the non-pharmacological management of CIE’s

A
  • address the modifiable risk factors
    -temporarily discontinue lens wear as this can resolve signs and symptoms within 48 hrs
    -advise against extended CL wear
    -evaluate lens fit and care regime
    -reinforce education concerning lens hygiene and wearing schedules
    -warn about possibility of recurrence as if condition recurs, then switch to daily disposables
    -lid hygiene if blepharitis is present
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41
Q

give the pharmacological management of CIEs

A

-ocular lubricants for symptomatic relief
-topical antibiotic may be indicated if blepharitis present

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42
Q

what is the aetiology of bacterial keratitis

A

sight threatening infection of the cornea

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43
Q

what are the most commen bacterial corneal pathogens with their types

A

-Pseudomonas sp. (Gram -ve)
-Staphylococcus sp. (Gram +ve)
-Streptococcus sp. (Gram +ve)

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44
Q

What are the predisposing factors of bacterial keratitis?

A
  • Contact lens wear
  • Ocular surface disease, ocular trauma/surgery
  • Immunocompromised
  • Lid margin infection
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45
Q

What are the most common fungal corneal pathogens?

A

-Candida sp. (yeast-like)
-Fusarium sp. (filamentous)
- Aspergillus sp (filamentous)

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46
Q

what are the predisposing factors of fungal keratitis specifically?

A

-being immunocompromised
-having had a trauma involving organic materials

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47
Q

what are signs that are specific to fungal keratitis?

A

-deep lesions with a feathery edge
-raised profile
-satellite lesions
-endothelial plaque

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48
Q

what are the symptoms of bacterial/ fungal keratitis?

A

-pain (usually acute onset and quickly gets worse)
-redness
-photophobia
-blurred vision (if lesion is on visual axis)
-discharge
-yellow spot on cornea

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49
Q

what are the signs of both bacterial/ fungal keratitis?

A

*Lid oedema
* Epiphora
* Discharge (mucopurulent or purulent)
* Conjunctival hyperaemia and infiltration
* Corneal lesion usually single (central or mid-
peripheral)
* Excavation (cavity) of epithelium, Bowman’s layer, stroma
(tissue necrosis)
* Stromal infiltration beneath lesion
* Stromal oedema with folds in Descemet’s
membrane
* Anterior chamber activity (flare, cells, hypopyon or
coagulum if severe)

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50
Q

what is the non-pharmacological management of bacterial/ fungal keratitis?

A

remove CLs but keep them and the case to determine the culture)

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51
Q

what are the non pharmacological management techniques of bacterial/ fungal keratitis?

A

-emergency referral to secondary care

52
Q

what are the predisposing factors of acanthamoeba keratitis?

A

-wearing CLs
-* inadequate contact lens disinfection
* use of non-sterile solutions
* tap water rinsing of lenses and/or storage cases
* contamination of storage case with bacteria and fungi (± biofilm) which provide substrate for
Acanthamoeba
* exposure to shower, pool, or hot tub water
-corneal trauma with exposure to soil or contaminated water

53
Q

what are the symptoms of AK?

A

*Pain (may be severe and out of proportion to degree of ocular inflammation; may also be painless in the early stages)
* Visual disturbance/loss, Redness, Watery eye, Photophobia
* May be a long history and condition may be misdiagnosed as herpetic, bacterial or fungal keratitis

54
Q

what are the signs of AK?

A

-conjunctival and limbal hyperaemia
-epiphoria
-reduced VA in later stages

55
Q

what are the early signs of the corneal lesions of AK?

A

*punctate epitheliopathy
* epithelial or subepithelial infiltrates
* pseudodendrites
* radial keratoneuritis (infiltrates along corneal nerves)
* recurrent breakdown of the corneal epithelium

56
Q

what are the later signs of corneal lesions of AK?

A
  • deep inflammation of the cornea consisting of a central
    or paracentral ring-shaped or disciform stromal infiltrate
    or abscess
  • stromal thinning
  • extension of inflammation into sclera
  • anterior chamber cells and flare
  • hypopyon (inflammatory cells in anterior chamber of eye)
57
Q

what is management for AK?

A

-remove CLs
-refer to secondary care EMERGENCY

58
Q

what are the two types of viral keratis?

A

hepes simplex keratitis and herpes zoster ophthalmicus

59
Q

What are the two types of of Herpes simplex virus? (HSV)

A

HSV-1 mainly infects mucous membranes ‘above the waist’

HSV-2 mainly infects mucous membranes ‘below the waist’

60
Q

what are the predisposing factors of HSK?

A
  • Poor general health, immunodeficiency, fatigue, steroids, immunosuppressive drugs, previous HSV
    infection
  • Aggravating factors – UV light, fever, extreme heat/cold, infection, trauma
61
Q

what are the symptoms of HSK?

A
  • Usually unilateral, rarely bilateral
  • Variable symptoms, can include pain, burning, irritation, photophobia, blurred vision, redness, reduced
    VA
62
Q

what are the epithelial signs of HSK?

A

-Initial punctate lesions, coalescing into a dendriform pattern
-* Dendritic ulcer, single or multiple opaque cells arranged in a stellate pattern progressing
to a linear branching ulcer, terminal bulbs may be visible
* Dendritic lesions stain with fluorescein
* Associated with reduced corneal sensitivity

63
Q

what are the stromal signs of HSK?

A
  • Stromal infiltrates, vascularization, oedema and opacification
  • Non-necrotising oedma is localized & often self-limiting,
  • Necrotizing inflammation is widespread, infection progressed to ulceration, necrosis and
    possible perforation
64
Q

what is the most severe sign of HSK?

A

metaherpetic ulcer

65
Q

what is the management for herpes simplex keratitis?

A
  • Aciclovir 3% ointment (continue for 3 days after healing complete)
  • Gangiclovir 0.15% ophthalmic gel (continue for 7 days after healing complete)
    *emergency referral if the stroma is involved or the Px is a child, contact lens wearer or has bilateral infection
66
Q

what is herpes zoster infection?

A

involvement of the ophthalmic division of the trigeminal nerve due to infection

67
Q

what microbe causes HZO?

A

human herpes virus -3 (HHV-3)

68
Q

what are the predisposing factors of HZO?

A

-age
-being immunocompromised

69
Q

what are the symptoms of HZO?

A
  • Pain and altered sensation (often described as “tingling“, “burning” or
    “shooting”) of the forehead on one side
  • Rash affecting forehead and upper eyelid appears a day to a week later
    General malaise, headache, fever
  • Ocular symptoms in acute phase: discomfort, discharge, redness, pain,
    photophobia
70
Q

what are the signs on the skin with HZO?

A
  • unilateral painful, red, vesicular rash on the forehead and upper eyelid, does
    not cross the midline, crusts after 2-3 weeks
  • Hutchinson’s sign, (indicating nasociliary nerve involvement) skin lesions on the side of the tip of the nose, correlates strongly with ocular involvement.
71
Q

What are the ocular signs of HZO?

A

*Early onset or within one month after the onset of the skin rash therefore
patients need to be monitored
* Mucopurulent conjunctivitis (common), associated with vesicles on the lid
margin; usually resolves within 1 week
* keratitis causing punctate epithelial – early sign, pseudodendrites – fine, multiple stellate lesions (around 4-6 days), disciform – 3 weeks after the rash (occurs in 5% of cases), reduced corneal sensation (neurotrophic keratitis), occurring in approximately 13% of HZ keratitis cases
* Episcleritis occurs in around one third of cases

72
Q

for HZO, what is the management?

A

-advice avoidance of contact with elederly, pregnant or immunocompromised people
-advice good diet and lots of fluids
-topical lubricant for ocular symptoms
-pain relief like paracetamol
-emergency referral to GP for systematic anti viral treatment for acute skin lesions as this will reduce percentage of eye disorders if this gets treated within 72hrs of onset
-maintain low threshold to refer to secondary care

73
Q

For HZO, when would you refer to secondary care?

A

-if deeper cornea involved
-anterior uveitis present
-raised IOP

74
Q

name 2 conjunctival infections

A

-viral conjunctivitis
-bacterial conjucntivitis

75
Q

name a conjunctival inflammation

A

allergic conjunctivitis

76
Q

name 5 conjunctival degenerations

A

➢ Pinguecula
➢ Pterygium
➢ Retention cyst
➢ Chalasis
➢ Concretions

77
Q

what are the three non-infectious types of conjucntivitis?

A

-allergic
-toxic
-autoimmune

78
Q

what are the signs of viral conjunctivitis?

A
  • Watery discharge
  • Conjunctival hyperaemia (intense?) and chemosis
  • Follicles on palpebral conjunctiva
  • Petechial (pin-point) subconjunctival haemorrhages
79
Q

what are the symptoms of viral conjunctivitis

A
  • May be preceded by ‘flu-like’ symptoms
  • Redness, discomfort (burning/grittiness), watering
  • Often unilateral at first, becoming bilateral. First eye usually more affected.
  • Systemic malaise (overall feeling weakness/unwell)
80
Q

What are the management points for viral conjunctivitis?

A

Advise self-limiting, resolving in 1-2 weeks
* Hygiene advice – highly contagious
* Do not share towels/pillows
* Avoid close contact if working in patient-facing roles
* No recommended exclusion period from school or nursery
* Cold compress and lubricants for symptoms
* Discontinue contact lens wear until resolved
* Antibacterial agents not effective in viral conditions
* Current antivirals not effective in adenovirus infection

81
Q

What are the signs of bacterial conjunctivitis?

A

-thick mucopurulent discharge
-lid crusting
-conjunctival hyperaemia most obvious in the fornices
-mild papillary reaction

82
Q

what are the symptoms of bacterial conjunctivitis?

A
  • Redness, discomfort (burning/grittiness)
  • Vision may be blurred by discharge
  • Sticky eyelids/lashes (may stick closed overnight)
  • Usually bilateral but one eye may be affected 1-2 days before the other
83
Q

what are the management options for bacterial conjunctivitis?

A
  • Advise self-limiting, resolving in 5-7 days without treatment
  • Return if symptoms persist beyond 7 days
  • Hygiene advice – contagious
  • Do not share towels/pillows
  • No recommended exclusion period from school or nursery
  • Bathe/clean eyelids to remove crusting
  • Cease CL wear until resolved
  • Topical antibiotics?
84
Q

what antibiotics would you give to someone with bacterial conjunctivitis?

A

Chloramphenicol 0.5% (eyedrop) or 1% (ointment)
* Azithromycin 1.5%
* Fusidic acid 1% (note: high cost and narrower spectrum of activity

85
Q

what are the two types of allergic conjunctivits?

A

acute and chronic

86
Q

what are the two types of chronic allergic conjunctivitis?

A

seasonal and perennial

87
Q

what are the 4 features that make up the aetiology of acute conjunctivits?

A

-type I IgE-mediated response
-common in children
-self limiting
-allergen is often unidentified

88
Q

what are the signs of acute allergic conjunctivitis?

A
  • Lid oedema and erythema
  • Conjunctival hyperaemia and chemosis
  • Watery or mucoid discharge (mild)
  • Usually no papillae
  • No corneal involvement
89
Q

what are the symptoms of acute allergic conjunctivitis?

A

*Sudden eyelid swelling
* Ocular itching
* May be unilateral (if direct contact response)

90
Q

how do you manage acute allergic conjunctivitis?

A
  • Reassure patient
  • Most cases resolve spontaneously within a few hours
  • Advise against eye rubbing
  • Cool compress to relieve symptoms
  • If known allergen, avoid future exposure
91
Q

what kind of immune response does chronic conjunctivitis trigger?

A

type I hypersensitivity (IgE-mediated) reaction to airborne allergens

92
Q

how do the symptoms of chronic conjunctivitis come about and what are they?

A

Conjunctival mast cell degranulation releases histamine, causing:
-dilation of vessels
-increased permeability of blood vessels -itching

93
Q

What are the predisposing factors of chronic conjunctivitis?

A

History (personal or family) of allergic disease (hay
fever, asthma, eczema, food or drug allergy)
* Allergic rhinitis

94
Q

what are the signs of chronic conjunctivits?

A
  • Mild to moderate lid oedema
  • Hyperaemia and chemosis of conjunctiva
  • Diffuse papillary reaction
  • No corneal involvement
94
Q

what are the symptoms to chronic conjunctivitis?

A
  • Itchy eyes (main symptom)
  • Red eyes, watering
  • Sneezing, watery nasal discharge
  • Timing of symptoms (seasonal vs perennial
94
Q

how do you manage chronic conjunctivitis?

A
  • Identify allergen(s) – careful H+S and diary matching to pollen calendars
  • Avoid allergen if possible
  • Advise against eye rubbing
  • Cool compress and ocular lubricants to relieve symptoms
  • Topical mast cell stabilisers – sodium cromoglicate 2%; lodoxamide 0.1%
  • Topical antihistamines – antazoline 0.5%
  • Combination – olopatadine 0.1%; ketotifen 0.025%
  • Topical NSAID – diclofenac sodium 0.1%
  • Systemic antihistamine (oral) – cetirizine; loratadine
94
Q

is seasonal or perennial conjunctivitis more common?

A

less common and also less severe

94
Q

how are seasonal and perennial conjunctivitis different?

A

seasonal is caused by seasonal allergens like grass and pollen. Perennial is caused by non-seasonal allergens like dust mites or animal dander

94
Q

what are the signs of pinguecula?

A
  • Bilateral, more commonly nasal, interpalpebral
  • Conjunctival thickening; elevated and less transparent
  • Mild hyperaemia?
95
Q

what are the predisposing factors for pinguecula?

A

-older age, male
-UV so being closer to the equator and occupation/ lifestyle
-chronic irritation from dust/ wind
-contact lens wear

95
Q

what are the symptoms for pinguecula?

A

Asymptomatic? Or mild foreign body sensation
* Occasional cosmetic concern

96
Q

what are the differential diagnoseses for pinguecula?

A

-pterygium
-retention cyst

97
Q

what are the management plans for pinguecula?

A
  • Reassure patient - benign
  • UV protection advice
  • Cold compress if inflamed
  • Ocular lubricants
98
Q

what do you prescribe for pingueculitis?

A

mild topical steroid

99
Q

what are the predisposing factors for pterygium?

A

-older age, male
-UV
-dry arid climate

100
Q

what are the signs for pterygium?

A
  • Bilateral, usually nasal, asymmetrical
101
Q

what are the symptoms for pterygium?

A
  • Asymptomatic? Or mild irritation
  • With-the-rule astigmatism
  • Severe cases: extend over visual axis
    *cosmetic concern
102
Q

What are the management options for ptreygium?

A

-* UV protection advice
* Cold compress if inflamed
* Ocular lubricants
* Severe cases: surgical excision

103
Q

what are the management options for a retention cyst if it becomes problematic?

A

-topical anaesthetic
-hypodermic needle

104
Q

what are the signs of chalasis?

A

Fold of redundant conjunctiva, often protrudes over lid margin

105
Q

what are the symptoms of chalasis?

A

watering if punctum is obstructed causing foreign body sensation

106
Q

what causes chalasis?

A

mechanical stress and dry eye

107
Q

what are the management options for chalasis?

A
  • Ocular lubricants, treat blepharitis
  • If severe, conjunctival resection (surgery)
108
Q

what are concretions?

A

small yellow/white lesions on the palperbral conj.

109
Q

what are the predisposing factors for concretions?

A

being 50+
-chronic inflammation like conjunctivitis or old chalazion

110
Q

what are the signs of concretions?

A

Small (<1-2mm) yellow/white bodies with distinct edges
* Appear larger if confluent

111
Q

what are the symptoms of concretions

A

-asymptomatic
-if they erode through eopithelium you get epiphoria and hyparaemia

112
Q

what are the differential diagnoses for concretions?

A

-inclusion cysts
-follicles

113
Q

what is the management plans for concretions

A

usually nothing but if symptomatic then use ocular lubricants

114
Q

how can you remove eroded concretions?

A

sit the patient under the slit lamp and administer topical anaesthetic to remove them with a hypodermic needle

115
Q

what is a subconjunctival haemorrhage?

A

a rupture if the conjunctival/ episcleral blood vessels which causes bleeding into the subconjunctival space

116
Q

what are the main spontaneous causes of a subconjunctival haemorrhage?

A

-idiopathic
-coughing/ straining
-systemic vascular disease like diabetes or hypertension
-medication like anticoagulants

117
Q

what are traumatic causes of subconjunctival haemorrhage?

A

-injury
-eye rubbing
-ocular surgery/ procedure
-contact lens handling injury

118
Q

what are the signs for subconjunctival haemorrhage?

A

Localised or diffuse red area, usually temporal or inferior
* Posterior border visible
* Usually unilateral
* No discharge

119
Q

what are the symptoms for subconjunctival haemorrhage?

A
  • Usually painless, sometimes mild ache or irritation
  • Patient concern/alarm
120
Q

what are the differential diagnoses for subconjunctival haemorrhage?

A
  • Acute haemorrhagic conjunctivitis (viral, usually bilateral)
  • Retrobulbar haemorrhage
121
Q

how could you manage subconjunctival haemorrhage?

A
  • Reassure patient (self-limiting), usually resolves in 1 - 2 weeks
  • Cold compress for discomfort
  • Ocular lubricants
  • Return if problem doesn’t resolve or recurs