Principles of drug action Flashcards
What are the properties of an ideal drug?
-easy to administer
-effective
-safe
-reversible action
-low cost
-chemically stable
-does not interact with other drugs
-predictable
What is the definition of a receptor?
a target molecule through physiological mediators (e.g. NTs, hormones) produce their effects
how is a dose response curve an example of a macroscopic effect?
it creates a pattern where any given ligand molecule has a choice of receptors which to bind to when the receptors are in large numbers
what is the dose response relationship?
if a drug has a high potency, a low dose is enough to produce a large response and vice versa
where can i find the equillibrium equation?
in the google doc
how is the sigmoidal shape on a dose response curve able to be represented?
by doing Log Dose on the x axis instead of just dose
what do receptors bind to?
ligands
what is affinity = in terms of biochemical analysis and what does this tell you?
affinity =1/Kd where Kd is the equillibrium constant
drugs that bind tightly have a low equilibrium constant
what is the definition of affinity?
tendancy to bind to receptors
what is the definition of efficacy?
ability of the drug receptor complex to achieve an active response
what do the x and y axis of a dose (log scale) response curve tell you?
Potency can be measured along the horizontal axis whereas efficacy can be measured along the vertical axis
what is an agonist? What’s its efficacy?
a drug that binds to a receptor, activating it and so initiates a response, efficacy is significant
what is an antangonist? what is it’s efficacy?
An antagonist is a drug that binds to receptor but does not initiate a response by occupying / blocking the receptor, efficacy is 0
what is potency?
the quantity of drug that must be administered to produce a specific effect
