Thalassemia Flashcards
Alpha Thalassemia Minor (Silent Carrier) HgB Produced
normal
Alpha Thalassemia Minor (Silent Carrier) Gene Deletions
1
Alpha Thalassemia Minor (Silent Carrier) Peripheral Blood Picture
Normal or slightly microcytic
Alpha Thalassemia Minor HgB produced
normal or some HgB H
Alpha Thalassemia Minor Gene Deletions
2
Alpha Thalassemia Minor Peripheral Blood Picture
- micro/hypo
- target cells
- BSTP
Alpha Thalassemia major “Hgb H Disease” Hgb Produced
up to 40% Hgb H
Alpha Thalassemia major “Hgb H Disease” Gene Deletions
3
Alpha Thalassemia major “Hgb H Disease” Peripheral Blood Picture
- micro/hypo
- increased retics
- BSTP
Hydrops Fetalis (Fatal before or shortly after birth) Hgb Produced
Hgb Barts (4 gamma)
Hgb Portland (Embryonic Hgb-2 zeta, 2 gamma)
Hydrops Fetalis (Fatal before or shortly after birth) Gene Deletions
4
Hydrops Fetalis (Fatal before or shortly after birth) Peripheral Blood Picture
- micro/hypo
- NRBCs
Constant Spring Hgb Produced
Hgb CS
Constant Springs Gene Deletions
2
Constant Springs Peripheral Blood Picture
- mild anemia
- elongation of chains
Beta Thalassemia Major “Cooley’s Anemia” Homozygous Genotype
B+B+ or B0B0
Beta Thalassemia Major “Cooley’s Anemia” Homozygous Hgb produced
HgB F: 20-90%
Increased Hgb A2
Increased HgbA2
HgbF: >90%
Beta Thalassemia Major “Cooley’s Anemia” Homozygous Peripheral Blood Picture
- hypo/microcytic
- increased NRBCs
- increased retics
- target cells
- BSTP
Beta Thalassemia Minor “Cooley’s Trait” Heterozygous Genotype
B+B or B0B
Beta Thalassemia Minor “Cooley’s Trait” Heterozygous Hgb Produced
HgbA2: 3-7%
HgbF: 2-6%
HgbA: decreased
Beta Thalassemia Minor “Cooley’s Trait” Heterozygous Peripheral Blood Pictures
- hypo/microcytic
- occasional NRBC
- targe cells
Beta hgb/B Thalassemia Genotype
Mild Sickle Cell Anemia
Beta hgb/B Thalassemia Hgb Produced
HgbA2: 3-7%
HgbF: 2-6%
HgbA: decreased
