Hemoglobinpathies Flashcards
1
Q
S-Disease affect on peripheral blood
A
- decreased H:H
- increased retic
- sickle cells, target cells, H-J bodies
1
Q
S-Disease (SS) chain structure
A
2 alpha; 2 beta
2
Q
S-Disease electrophoresis
A
S- 85-100%
F- <15%
A2- 2.5%
3
Q
Other lab tests for S-Disease
A
+ Dithionite solubility
4
Q
S-Trait (AS) affect on peripheral blood
A
target cells
5
Q
S-trait (AS) electrophoresis
A
S- 35-45%
A- 50-65%
6
Q
S-Trait (AS) other lab tests
A
+ dithionite solubility
7
Q
C-Disease (CC) chain structure
A
2 alpha; 2 beta
8
Q
C-Disease (CC) affect on peripheral blood
A
- target cells
- increased retics
- decreased H:H
- HGB C Crystals
9
Q
C-Disease (CC) Electrophoresis
A
C- 93-100%
F- <7%
10
Q
C-Trait (AC) affect on peripheral blood
A
- target cells
- mild hypochromic
11
Q
C-trait (AC) electrophoresis
A
C- 35-45%
A- 55-65%
12
Q
SC Disease Chain Structure
A
2 alpha; 2 abnormal beta
13
Q
SC Disease affect on peripheral blood
A
- sickle cell
- target cell
- HGB C Crystals
14
Q
SC Disease electrophoresis
A
S- 45-50%
C- 45-50%
F- 5-8%
15
Q
SC Disease other lab tests
A
+ dithionite solubility
