Knowledge Burst Unit 6

Question 1

What are the major hematopoietic sites in the fetus and in the adult?

Answer 1

Fetus= liver
Adult= bone marrow

Question 2

How do cells get from the bone marrow into peripheral circulation?

Answer 2

Mature cells squeeze through spaces in the vessel endothelial lining

Question 3

When hematopoiesis occurs in the liver in an adult, it is called:

Answer 3

Extramedullary

Question 4

Where are developing red cells located in the bone marrow?

Answer 4

Adjacent to the outer surfaces of the vascular sinuses

Question 5

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

Answer 5

The absent spleen cannot “pit” or remove the normally formed inclusions

Question 6

Why does surgical removal of the spleen cause people to have an increased platelet count?

Answer 6

The 30% of platelets normally stored in the spleen are freely circulating

Question 7

What condition is most associated with autosplenectomy?

Answer 7

Sickle Cell Anemia

Question 8

Which of the following is a morphologically identifiable precursor cell using Wright stain?

Answer 8

Promyelocyte