Textbook Chapter 14 Coronaviruses

Question 1

coronaviruses are responsible for what?

Answer 1

common colds, veterinary diseases, and an outbreak of SARS (severe acute respiratory syndrome)

Question 2

coronaviruses have the largest known what?

Answer 2

genomes of RNA

Question 3

coronaviruses have what kind of nucleocapsids?

Answer 3

helical nucleocapsids, unusual for positive strand RNA viruses. some have additional spherical capsid

Question 4

the replicase genes are translated to produce what?

Answer 4

two overlapping polyproteins, which are cleaved to generate up to 16 distinct viral proteins

Question 5

all viral structural proteins of coronaviruses are made from what?

Answer 5

3’ coterminal nested set of subgenomic messenger RNAs

Question 6

subgenomic messenger RNAs what copies of what?

Answer 6

subgenomic RNAs transcribed from genome RNA by an unusual discontinuous transcription mechanism

Question 7

like other positive strand RNA viruses, coronaviruses induce what?

Answer 7

intracellular membrane proliferation and viral RNA replication takes place in association with these membranes

Question 8

coronaviruses virions are assembled where?

Answer 8

within the endoplasmic reticulum/golgi intermediate compartment and secreted via vesicles that fuse with the cell membrane