Textbook Chapter 12 Flaviviruses Flashcards
Flaviviruses cause severe human diseases like what?
yellow fever, japanese enchphalitis, dengue fever, and hepatitis
how are most flaviviruses except Hep C transmitted?
through mosquitos or ticks
Which virus entered the US in 1999 and through mosquito to bird transmission cycle expanded its presence into mos tof the US and Canada?
West Nile Virus
The flavivirus particle is covered in what?
a flat layer of envelope proteins arranged with icosahedral symmetry giving it a golf ball shape
how do flaviviruses enter the cell?
by uptake into endosomal vesicles, at low pH the envelope protein rearranges from a dimer into a fusion active trimer
how are all flavivirus proteins synthesized as?
as single polyprotein that is cleaved into 10 functional viral proteins by viral and cellular proteinases
flavivirus RNa synthesis takes place in association to what?
in association with cytoplasmic membranes
where does assembly of flavivirus virions take place at?
on membranes of the Endoplasmic reticulum
how does maturation of virions happen?
cleavage of the premembrane protein as they pass through the trans-golgi network
