Textbook Chapter 13 Togaviruses Flashcards
how are most togaviruses transmitted?
through warm blooded hosts by mosquitos
togaviruses can cause serious disease such as what?
encephalitis in humans and horses
the protein subunits of what of togaviruses are arranged with icosahedral symmetry?
nucleocapsid and the envelope
togaviruses synthesize what through translation of full length genome RNA?
RNA polymerase, capping enzyme, and proteinases
how are structural proteins (capsid and envelope proteins) synthesized?
by translation of an abundant subgenomic RNA
togavirus RNA synthesis is carried in assoication with that?
in association with membranes
in vertebrates, how are virions made?
by budding of nucleocapsids through the cytoplasmic membrane
a signal on the genome RNA (packaging sequence) binds where?
to a sequence in the capsid protein to ensure efficient packaging of the viral genome RNA into the nucleocapsid
an alternative assembly model proposes that a complex between genome RNA and capsid proteins form what?
a nucleocapsid only upon interaction with viral envelope proteins at the cytoplasmic membrane
togavirus (alphavirus) expression vectors have promising potential uses for what?
vaccines or to express useful or toxic proteins
