tetracyclins

Question 1

1st gen. chloro floro carbons damage o2 and dermis

Answer 1

tetracycline
oxytetracycline
chlortetracycline
demeclocycline

Question 2

2nd gen. mini metha maar rahi ha k oxy se doxy hu giya ha

Answer 2

minocycline
methacycline
doxycycline

Question 3

3rd generation

Answer 3

glycylcyclin
syn gylcyl amido der. of minocycline
not available

Question 4

MOA

Answer 4

entry through porins g- bact.
entry in g+ bact. unknown
energy dependent 
bind reversibly to 30S subunit of ribosome 
prevent attachment of t- RNA

Question 5

resistance

Answer 5

efflux pump
dec. penetration
enzymatic deactivation of drug
dec. access due to ribosome protecting proteins

Question 6

absorption

Answer 6

incomplete

best absorbed on empty stomach

Question 7

on empty stomach
chlortetracycline
oxy
demeclo
tetra
doxy
mino

Answer 7

30%
60-80% (D)
95 -100%

Question 8

impaired absorption

Answer 8

dairy products
al hydro oxide gel
ca mg iron zn salts
bismuth subsalicylates

Question 9

widely distributed

Answer 9

throughout body

found in secretion; prostate and urine

Question 10

accumulated in

Answer 10

reticuloendothelial cells; liver + spleen + bone marrow
bones
dentin + enamel - unerupted teeth

Question 11

can cross

Answer 11

placental barrier

found in breast milk

Question 12

exretion

Answer 12

primarily by kidney

Question 13

liver met.

Answer 13

minocycline

Question 14

g+ organisms
SHY FIPPi Bought a Cute Little Vallet
(anaerobes + aerobes)

Answer 14

s. pneumonia
h. ducreyi
helicobacter pylori
yersenia; pestis + eneterocolitica
francisella tularensis
h. influenza
p. multocida
pseudomonas pseudomallie
brucella
compylobacter jejuni
liogenella pneumophilla
vibrio cholera

Question 15

rickettsia

Answer 15

rocky mountain spotted fever
q fever
scrub typhus
typhus

Question 16

miscellaneous

SuB TuM sa ha

Answer 16

spirochetes 
borellia 
treponema pallidum
treponema pertenue
mycobacterium marinum

Question 17

effect on intestinal flora

Answer 17

incomplete absorption
high lvls reach bowel
effect intestinal flora
yellow greenish discoloration to stool
soft consistency
pseudomem. colitis - c. dificile

Question 18

rickettsia

Answer 18

rocky mountain spotted fever
typhus
rickettisial pox
q fver

Question 19

mycoplasmal inf.

Answer 19

mycoplasma pneumonia

Question 20

chlamydia

Answer 20

lymphogranuloma venerum -doxy
pnuemonia + bronchitis + sinusitis -c. pneumonia
trachoma
non specific urithritis - c. trachomatis

Question 21

sexualy transmitted diseases

Answer 21

uncomplicated gonococcal inf.

3rd gen. cephalosporins gen. prescribed

Question 22

bacilary inf.

Answer 22

brucellosis
tularemia
cholera

Question 23

acne

Answer 23

propioni bact.

Question 24

toxicities

KAPIL DeV G

Answer 24

kidney disorder - fanconi syn.
anabolic effects
phototoxicity
inc. intracranial hypertension - until drug use
liver toxicity - oxy + tetra less toxic
dental discoloration/ hypoplasia /hypersensitivity
vesitubuler dysfunc. - minocycline + ataxia
GI disturbances + pseudomem. colitis

Question 25

contraindications

Answer 25

pregnant ladies

children under 8 yrs