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protein syn. inhibitors > chloramphenicol > Flashcards

chloramphenicol Flashcards

1
Q

MOA

A 
enter bact. through facilitated diffusion
bind to 50S subunit reversibly
inhibit peptidyl transferase rx
inhibit peptide bond formation
bacteriostatic
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2
Q

HaaN SaBR kero

A

h. influenza
n. gonorrhea
n. meningitides
s. typhi
brucella
bordetella pertussis
rickettsia NOT CHLAMYDIA

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3
Q

anaerobic bact.

A

g+ cocci
g- rods
clostridium
b. fragilis

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4
Q

Enterobacteriaceae

A 
v. cholera -VerM
mycoplasma
pseudomonas- P
pseudomalli
p. mirabilus
e. coli _E
shigella - St
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5
Q

oral administration

A

palmitate chloramphenicol
pro drug
hydrolyzed in intestine - yield free drug
rapidly + completely absorbed

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6
Q

half life

A

2.5 hrs

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7
Q

dose

A

50-100 mg/kg/d

divided into 4 equal doses

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8
Q

1g produces blood lvl

A

10-15mcg/ml

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9
Q

g+ bact. inhibited

A

1-10mcg/ml

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10
Q

g- bact. inhibited

A

0.2-5mcg/ml

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11
Q

parental administration

A

chloramphenicol succinate
prodrug - hydrolyzed
distributed to blood and body cavities CSF +CNS
met. in LIVER - glucorunidation
active drug 10% + metabolites - urine +bile
dec. in liver disease + premature babies + infants less than 1 wk

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12
Q

therapeutic use

A 
rocky mountain spotted fever
typhus
typhoid fever
bact. meningitis (cheapest treatment)
topical - bact. eye inf.
staph brain abscess - single dose (DOC)
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13
Q

meningitidus

A

sp
nm
hi

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14
Q

resistance

A

chloramphenicol acyl transferase - plasmid encoded
destroy drug
less likely
mutant strains may develop

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15
Q

toxicities

cool smart boy in girls arena

A 
chloramphenicol
superinf.
bone marrow toxicities
grey baby syn
aplastic anemia
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16
Q

rare toxicities

A

blurring of vision
optic neuritis
digital paresthesis

17
Q

Jarisch – Herxheimer Reaction (HERX) when adm for
syphilis
leptospirosis
relapsing fever

A

fever +chills + nausea + vomiting
headache tachycardia flushing
myalgia + exacerbation of skin lesion

18
Q

inhibit

A

cytochrome p450 enzyme

met of drugs by cyt. p450

19
Q

prolong

A

half life + serum conc
warferin
phenytoin
chlorpropamide

protein syn. inhibitors (6 decks)

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