clindamycin Flashcards
1
Q
MOA
A
bind to 50S
inhibit aminoacyl translocation process
interfere formation of initiation complex
2
Q
resistance
A
Mutation of the ribosomal receptor site
Modification of receptor by methylase
Enzymatic inactivation of drug
Poor permeability of outer membrane (gram-negative aerobic species)
3
Q
spectrum
A
Pneumocystis jiroveci
strep. staphylo
bacteriodes
anaerobe
