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BBDA 5 > Tetracyclines and Macrolides > Flashcards

Tetracyclines and Macrolides Flashcards

1
Q

What are the Tetracyclines?

A

Tetracycline
Doxycycline
Minocycline
Demeclocycline

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2
Q

Tetracycline MOA?

A

Protein synthesis inhibitor (Binds 30S subunit of bacteria ribosome)
Bacteriostatic

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3
Q

Tetracycline Spectrum

A

Gram+ : Strep, Staph
Mino & Doxy cover MRSA

Gram -: Limited
Other: Mycoplasma & Chlamydia

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4
Q

Tetracycline PK

A

Doxy & Mino higher bioavailability

Take on empty stomach
Impaired by Ca,Mg,Fe,Al
Renal/Fecal
Doxy can be used in renal impairement

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5
Q

Tetracycline ADR

A 
GI
Photosensitivity
CNS
Hepatotoxicity
Teratogenic
Teeth discoloration
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6
Q

Tigecycline Spectrum

A

Gram +: Very Good
Gram -: Enterics
Anaerobes

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7
Q

Tigecycline PK

A

Not metabolized
No CYP interactions
Fecal

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8
Q

Tigecycline ADR

A

GI

Elevates liver function test

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9
Q

What are the macrolides?

A

Erythromycin
Clarithromycin
Azithromycin
Telithromycin

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10
Q

Macrolide MOA

A

Synthesis Inhibitor: Binds 50S unit

Bacteriostatic

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11
Q

Macrolide Spectrum

A

Gram +: Strep, Staph
Gram -: Good
Atypicals: Mycoplasma Legionella, Chlamydia

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12
Q

Macrolide PK

A

Take on empty stomach
Good distribution, No CNS-P
Erythro, Clarithro, Telithro extensive P450 inhibition

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13
Q

Macrolide ADRs

A 
GI
QT Prolongation
Ototoxicity
Metallic Taste
Hepatotoxicity
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14
Q

Clindamycin Spectrum

A

Gram +: Strep, Staph, (some MRSA)

Anaerobes

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15
Q

Clindamycin PK

A

hepatic

No CNS-P

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16
Q

Clindamycin ADRs

A

GI (C. Diff)

Rash

17
Q

Streptogramin Spectrum

A 
Gram + Only
Strep Staph (MRSA) Entero
18
Q

Streptogramin PK

A

IV Only
Inhibits P450
Bile

19
Q

Streptogramin ADRs

A

Phlebitis
Myalgia
Hyperbilirubinemia
GI

20
Q

Linezolid Spectrum

A

Gram +: Strep Staph (MRSA) Entero

21
Q

Linezolid PK

A

Renal

22
Q

Linezolid ADR

A

GI
Thrombocytopenia
Neuropathy
MAOI

23
Q

Tedizolid Spectrum

A

Staph (MRSA) Strep, Entero

24
Q

Tedizolid ADRs

A

Same as Linezolid

BBDA 5 (6 decks)

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