Glycopeptides & Lipopeptides Flashcards
1
Q
Vancomycin Spectrum
A
Gram+ only
MRSA/MRSE
C. Diff (oral form)
2
Q
Vancomycin PK
A
IV only unless for C. diff
Limited CNS-P
Renal
3
Q
Vancomycin ADRs
A
Infusion related flushing (Red Man)
Ototoxicity
Nephrotoxicity
4
Q
Telavancin Spectrum
A
Gram + Only
MRSA/MRSE, Enterococcus
Not for C. Diff
5
Q
Televancin ADRs
A
Nephrotoxicity Red Man QT prolongation Taste Disturbances Foamy Urine
6
Q
Dalbavancin Spectrum
A
Gram + Only
MRSA, S. epidermidis
Strep
Entero
7
Q
Dalbavancin PK
A
346 hour half life (2 dose series)
Renal
8
Q
Dalbavancin ADRs
A
Headache
Rash
GI
Infusion (better than Vanco)
9
Q
Oritavancin Spectrum
A
Same as Dalbavancin
10
Q
Oritavancin PK & ADR
A
10 day half life, single dose
Renal
ADR: Similar to Dalbavancin
Inhibits CYP2C
Induces CYP3A4
11
Q
Daptomycin Spectrum
A
MRSA, VRE
12
Q
Daptomycin PK
A
IV Only
Don’t give in Pulmonary infections
Renal
13
Q
Daptomycin ADRs
A
Myopathy
Myalgia
GI
Headache
