Aminoglycosides Flashcards
1
Q
What are the aminoglycosides?
A
Gentamicin Tobramycin Amikacin Streptomycin Neomycin
2
Q
Aminoglycoside Spectrum
A
Gram +: Strep, Staph, Entero
Gram -: Most aerobic gram-negatives
Synergistic with B-lactams and vancomycin
3
Q
Aminoglycoside PK
A
Cidal, [ ] dependent killing
Postantibiotic effect
Poor CNS-P
Renal
4
Q
Aminoglycoside ADRs
A
Ototoxicity
Nephrotoxicity
5
Q
Isoniazid PK
A
Antimycobacterial
good CNS-P
CYP450 inhibitor
Hepatic
6
Q
Isoniazid ADR
A
GI
Peripheral Neuropathy
Hepatitis
CNS
7
Q
Rifampin PK
A
Antimycobacterial
CYP450 Inducer
Biliary
8
Q
Rifampin ADR
A
Orange-Red sweat/urine
Flu-Like symptoms
Hepatotoxicitty
9
Q
Pyrazinamide PK
A
Antimicobacterial
Good CNS-P
Renal
10
Q
Pyrazinamide ADR
A
Hepatotoxicity
Hyperuricemia (gout)
GI
11
Q
Ethambutol PK
A
Antimcycobacterial
Good CNS-P w/inflammation
Renal
12
Q
Ethambutol ADR
A
Optic Neuritis (reversible)
