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Pharmocology - Joy > Tetracyclines > Flashcards

Tetracyclines Flashcards

1
Q

Tetracyclines that does require dose adjustment

A
  • tigecycline

- doxycycline

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2
Q

Give the short acting tetracyclines

A

Tetracyclines
Chlortetracycline
Oxytetracycline

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3
Q

Drug of choice for rickettsial infection

A

Tetracycline

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4
Q

Chief adverse effect of tigecycline

A

Nausea

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5
Q

Intermediate acting tetracycline

A

Demeclocycline

Methacycline

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6
Q

Long acting tetracycline

A

Doxycycline

Minocycline

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7
Q

MOA of tetracyclines

A

Binds reversibly to the 30S subunit of the bacterial hormone

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8
Q

Three mechanism of resistant to tetracycline

A

1) impaired influx or increased efflux by an active transport protein pump
2) ribosome protection due to production of proteins that interfere with tetracycline binding to the ribosome
3) enzymatic activation

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9
Q

Crystalline amphoteric substance of low sollubility

A

Free tetracylines

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10
Q

A glycycline and a semisynthetic derivative of minocycline

A

Tigecycline (100 mg loading dose, 50 mg every 12 hours)

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11
Q

Two types of transport that tetracycline do in order to enter in a microorganism

A 
Passive dissufion
Active transport (energy-dependent process)
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12
Q

Mode of administration of buffered tetracyclines

A

IV

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13
Q

Efflux pump-expressing gram negative species

A

Tet (AE)

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14
Q

Drugs that are resistant due to Tet (AE)

Susceptible to?

A

Older teracyclines, doxycyclines, minocyclines

Susceptible to Tigecycline

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15
Q

Substances that shortens the the halflife of doxycycline

A

Carbamazepine
Phenytoin
Barbiturate
Chronic alcohol ingestion

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16
Q

Mode of administration of tigecycline

A

IV

17
Q

Tetracyclines that are not impaired by food

A

Minocycline and doxycycline

18
Q

Tetracycline that has high concentration in tears and saliva

A

Minocycline

19
Q

Useful fo eradication of menigococcal carrier state

A

Minocycline (200mg daily for 5 days)

20
Q

What cephalosporin, in combination with doxycycline, is useful as a alternative treatment for gonococcal disease

A

Ceftriaxone

21
Q

Oral tetracycline of choice because it can be given twice daily and its absorption is not impaired by food

A

Doxycycline

22
Q

Oral dosage of tetracycline hydrochloride

A

0.25 - 0.5 g four time daily for 4 days: adults

20mg/kg/day: > 8 y/o

23
Q

Most common reasons for discontinuing tetracyclines

A

Nausea, vomiting and diarrhea

24
Q

Gram (+) organism coverage of teracycline

A

Streptococcus, staphylococcus, actinmyces, B. anthracis

Pharmocology - Joy (5 decks)

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