Cancer Chemotherapy - Dr. Julian

Question 1

A drug that needs good hydration of the patient to prevent bladder toxicity

Answer 1

Cyclophosphamide

Question 2

Chemical cystitis in cycliphosphamide is best treated with?

Answer 2

Mesna

Question 3

An alkalating drug that causes aseptic thrombophlebitis

Answer 3

Mechlorethamine

Question 4

A derivative of mechrethamine that is used for multiple myeloma.

Answer 4

Mephalan

Question 5

Alkalating agents that form DNA cross-links resulting to inhibition of DNA synthesis and fuction

Answer 5

Mechlorethamine
Mephalan
Thioteta
Cyclophosphamide
Bendamustine
Carmustine
Lomustine
Altretamine

Question 6

Alkalating agents that methylate DNA and inhibit DNA synthesis and function

Answer 6

Temozolamide
Procarbazine
Dacarbazine

Question 7

Alkalating agents that forms intrastrand and interstrand DNA crosslinks; binding to nuclear and cytoplasmic proteins

Answer 7

Ciplastin
Carboplatin
Oxaliplatin

Question 8

It requires force hydration with mannitol to prevent kidney damage

Answer 8

Ciplastin

Question 9

An antitumor antibiotic that forms complexes with iron while also bound to DNA oxidation of iron which gives rise to free radical

Answer 9

Beomycin

Question 10

A drug under epipodiohyllotoxin (topoisomerase II inhibitor) (G1-S phase)

Answer 10

Etoposide

Question 11

At what cell cycle phase taxanes act

Answer 11

M phase

Question 12

Drugs under taxanes

Answer 12

Albumin bound- paclitaxel
Cabazitacxel
Paclitaxel

Question 13

Antimetabolites act at what cell cycle phase?

Answer 13

S phase

Question 14

Bleomycin acts at what cell cycle phase?

Answer 14

M phase

Question 15

Drug classifications that are cell cycle non-specific

Answer 15

Alkalating agents
Antitumor antibiotics except bleomycin (G2-M phase)
Campothecins (topoisomerase 1 inhibitor)
Platinum analogs
Anthracyclines