Tetracyclines

Question 1

Short acting

Answer 1

• Chlortetracycline
• Oxytetracycline
• Tetracycline

Question 2

Intermediate acting

Answer 2

• Demeclocycline
• Methacycline

Question 3

Longer acting

Answer 3

• Doxycycline
• Minocycline

Question 4

1st line drug for

Answer 4

-Rickettsial infections (Rocky mountain spotted fever, Typhus fever, rickettsialpox and Q fever)
-Chlamydial infection : Psittacosis,
-Lymphogranuloma venereum
-Granuloma inguinale ( Calymm granulomatis)
-Nonspecific urethritis (caused by Ureaplasma urealyticum)
-Atypical pneumonia (caused by Mycoplasma pneumoniae)
-Lyme disease (caused by Borrelia burgdoferri)
-Recurrent fever (caused by Borrelia recurrentis) .

Plague- Combined with streptomycin

Tularemia- Combined with streptomycin

Brucellosis: It is treated with a combination of doxycycline with rifampin, gentamicin, or streptomycin

Question 5

2ND drugs for

Answer 5

❑ For amoebiasis along with metronidazole
❑ Doxycycline is combined with other antimalarial agents for treating chloroquine-resistant P. falciparum malaria. It is used alone for malarial chemoprophylaxis
❑ Peptic ulcer (caused by H. pylori)
❑ Acne vulgaris- Propionibacterium
❑ Cholera
❑ Anthrax

Question 6

Minocycline-

Answer 6

vestibular toxicity, skin pigmentation.

Question 7

Demeclocycline and doxycycline.

Answer 7

Phototoxicity