anti-thyroid

Question 1

Drugs inhibiting iodide trapping

Answer 1

• Thiocyanate
• Potassium perchlorate
• Iodides

Question 2

Drugs inhibiting thyroid hormone synthesis: Thioamides

Answer 2

• Propylthiouracil (PTU)
• Carbimazole
• Methimazole

Question 3

Drugs inhibiting thyroid hormone release

Answer 3

• Aqueous potassium iodide solution
• Lugol’s iodine

Question 4

Drugs inhibiting peripheral conversion of T4 to T3

Answer 4

• Propylthiouracil (PTU)
• Propranolol
• Hydrocortisone
• Iodinated contrast media
  like ipodate, iopanoic acid, diatrizoate

Question 5

Drug that destroy thyroid tissue

Answer 5

Radioactive iodine (131I)

Question 6

thyroid storm MANAGEMENT

Answer 6

• High doses of propylthiouracil (500–1000 mg loading, then 250 mg, 4–6 hourly)
• 5–10 drops of Lugols iodine 6–8 hourly for the first 10 days, should be given after administration of
  antithyroid drugs for rapid improvement of thyrotoxicosis in thyroid storm.
• Propranolol to control heart rate and inhibit other peripheral action of thyroid hormone.
  ✓ Shorter acting intravenous esmolol or diltiazem can be used to control heart rate when there are contraindications to b-adrenergic receptor antagonists.
• High doses of glucocorticoids (IV hydrocortisone 100 mg, 6 hourly or dexamethasone 2 mg, 6 hourly)
• Supportive measures (IV fluids, antipyretic, cooling blankets)

Question 7

Management of thyrotoxicosis during pregnancy

Answer 7

PTU OR METHIMAZOLE MINIMUM DOSE