Tetracyclines Flashcards
1
Q
in neutral solution, tetracyclines exist as ___
A
zwitterions
2
Q
what is the most common form of tetracyclines used for oral administration?
A
HCl salts
3
Q
why are tetracycline HCl salts encapsulated?
A
due to bitter taste
4
Q
in what pH conditions can tetracylines undergo epimerization?
A
4-8
5
Q
epitetracyclines have ___% of the activity of the natural form of tetracycline
A
5 (less potent)
6
Q
what 2 forms of tetracycline causes a Fanconi-like syndrome?
A
anhydrotetracycline and anhydro-4-epitetracycline
7
Q
are tetracyclines bacteriostatic or bacteriocidal?
A
bacteriostatic
8
Q
as logP increases, polarity ___
A
decreases
9
Q
as polarity ____, urinary excretion increases
A
increases
10
Q
What is the most common form of tetracycline?
A
hyclate
