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DAST 7 Exam 2 > Tetracycline AB - 5Qs > Flashcards

Tetracycline AB - 5Qs Flashcards

1
Q

Are Tetracyclines acidic/basic?

A

Neither.

They’re amphoteric that is, they can be acidic, basic/ neutral depending on the solution.

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2
Q

What carbons are modifiable?

A

4, 5, 6, 7

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3
Q

What may lead to inactivity of Tetracyclines?

A

Epimerization at C-4 leads to loss of activity

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4
Q

What also occurs at C-4?

A

Dehydration

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5
Q

What’s the toxic metabolite of tetracycline?

A

Epianhydrotetracycline

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6
Q

Which tetracyclines are not prone to dehydration

A

Minocycline and Doxycycline

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7
Q

What chelates tetracyclines that are prone to chelation?

A 
Mg2+
Ca2+
Fe2+
Al3+
Diary pdts
Antacids
Mineral supplements
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8
Q

MOA of tetracyclines

A

BacterioSTATIC

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9
Q

What are the Target for tetracyclines?

A

Inh protein synthesis after binding to bacterial 30s ribosomal subunit

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10
Q

What are tetracyclines to human in high concentrations?

A

Antianabolic in humans

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11
Q

What are the other targets of tetracycline?

A

Cytoplasmic membranes causing leakage into the cell

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12
Q

How’s resistance dev to tetracyclines?

A

R-factor mediated
Efflux pump
Oxidative enzymes (in some strains)

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13
Q

Are tetracyclines still popular?

A

Not anymore.

Minocycline and doxycycline are the ones most commonly used

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14
Q

When’s tetracycline considered 1st line?

A 
Chlamydia, Mycoplasma and Ureaplasma inf
Lyme dx
Cholera
Rocky Mountain spotted fever
Scrub typhus
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15
Q

When are tetracyclines used as prophylaxis?

A

Traveller’s diarrhea

Malaria

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16
Q

List AEs of tetracyclines

A 
Photosensitivity
Tooth and bone staining
GIT problems
Superinfection
Antianabolic
CNS effects
Thrombophlebitis
Serious liver damage
17
Q

Which tetracycline may be MOST responsible for photosensitivity?

A

Demeclocycline

18
Q

Which Tetratcycline is most responsible for CNS SEs

A

Monocycline

19
Q

Is tetracycline given to children and women of child-bearing age?

A

No.

Becuz it erodes weight bearing joints

20
Q

What’s the effect of high dose (2g/d IV) of tetracyclines in pregnancy?

A

Serious liver damage

21
Q

Is it best to use tetracyclines with food?

A

No.

Food, milk etc reduce absorption of tetracyclines

22
Q

Role of Tigecycline (Glycylcyclines)

A

For tetracycline-resistant org including MRSA

For complicated skin and soft tissue infection (SSSI)

DAST 7 Exam 2 (9 decks)

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