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DAST 7 Exam 2 > Anti-infective Spectrum of activity - 10Qs > Flashcards

Anti-infective Spectrum of activity - 10Qs Flashcards

1
Q

List the B-lactam that attack cell walls.

A

Penicillins
Cephalosporin
Carbapenems
Monobactams

ALL of them

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2
Q

List the Glycopeptides that attack cell walls.

A

Vancomycin

Telavancin

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3
Q

List the AB that attack cell membranes.

A

Daptomycin

Colisitin

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4
Q

List the ABs that attack 30s ribosome (Cytoplasm)

A

Tetracycline e.g. minocycline, doxycycline

Aminoglycosides e.g. Amikacin, tobramycin, gentamicin

Glycyclines e.g. Tigecycline

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5
Q

List the ABs that attack 50s ribosome (Cytoplasm)

A

Macrolides
Clindamycin
Quinopristin/Dalfopristin

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6
Q

List the ABs that attack 50s/Initiation complex ribosome (Cytoplasm)/ 23s subunits of 50s

A

Linezolid

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7
Q

List the ABs that attack DNA synthesis

A

Fluoroquinolones
Metronidazole
Trimethoprim/Sulfamethoxazole
Rifampicin

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8
Q

List the penicillins that are ANTIPSEUDOMONAS

A

Piperacillin

Ticarcillin

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9
Q

List the Cephalosporin that are ANTIPSEUDOMONAS

A

Ceftazidime
Cefepime
Ceftaroline

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10
Q

List the Carbapenems that are ANTIPSEUDOMONAS

A

Doripenem
Imipenem-cilistatin
Meropenem

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11
Q

List the Fluoroquinolones that are ANTIPSEUDOMONAS

A

Ciprofloxacin

Levofloxacin

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12
Q

List the Aminoglycosides that are ANTIPSEUDOMONAS

A

Amikacin

Tobramycin

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13
Q

List other AB that are ANTIPSEUDOMONAS

A

Aztreonam

Colisitin

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14
Q

List ABs that are active against MRSA

A 
IV Ceftaroline (Cephalosporin-B-lactam)
Sulfonamides (active against some strains of MRSA (CA-MRSA))
Vancomycin (Glycopeptides)
Linezolid
Daptomycin (cyclic Lipopeptides)
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15
Q

Which B-lactam is the exception to the short t1/2 of this group?

A

Ceftriaxone

Ertapenem

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16
Q

Which B-lactam is the exception to this Grp being primarily renally cleared?

A

Nafcillin
Oxacillin
Ceftriaxone

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17
Q

List ABs that are responsible for Above Diaphragm bugs (Anaerobes)

A

Natural Penicillins e.g. Pencillin G and V
Extended spectrum Penicillins e.g. Piperacillin and Ticarcillin
Lincosamides e.g. Clindamycin

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18
Q

List drug of choice for MSSA

A

Nafcillin
Oxacillin
Cefazolin IV

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19
Q

List ABs that are responsible for Below Diaphragm bugs (Anaerobes)

A

Metronidazole

20
Q

Which AB is both bacterioSTATIC and bacteriCIDAL

A

Oxazolidinones
Streptogramins
Chloramphenicol

21
Q

For the B-lactams, what’s the relationship btw MIC dependent killing and Time?

A

Time>MIC dependent killing

22
Q

Which AB is effective against Listeria?

A

Ampicillin

Sulfonamides

23
Q

List common gram tve m.o.

A

Staphylococcus
Streptococcus
Enterococcus

24
Q

List common gram -ve m.o.

A 
Haemophilus
E. coli
Neisseria
Proteus
Pseudomonas 
E
Kelbsiella
Moraxella

HENPEKM

25
Q

What AB covers coagulase negative staph?

A

Glycopeptides e.g. Vancomycin

26
Q

Which ABs have a broad coverage against anaerobes?

A

Amoxicillin/Clavulanate PO
Piperacillin/Tazobactam (Zosyn) IV
Moxifloxacin (Fluoroquinolones)
Lincosamides

27
Q

What AB may cuz bone marrow suppression and serotonin syndrome (if used with MAO active drugs)?

A

Oxazolidinones e.g. Linezolid

28
Q

What ABs is effective against VRE?

A

Oxazolidinones e.g. Linezolid

Cyclic Lipopeptides e.g. Daptomycin

29
Q

What ABs are effective against Pseudomonas and Acinetobactor?

A

Ceftazidime

Piperacillin

30
Q

What AB req central line access for administration?

A

Streptogramins e.g. Quinopristin+Dalfopristin

31
Q

What AB req regular CPK monitoring at baseline and weekly thereafter?

A

Cyclic lipoprotein e.g. Daptomycin

32
Q

What’s unique about Amikacin activity?

A

Mycobacterium activity

33
Q

What’s the 2nd line for TB?

A

Streptomycin

34
Q

What ABs req Therapeutic Drug Monitoring (TDM)?

A

Aminoglycosides e.g. Gentamicin

Glycopeptides e.g. Vancomycin

35
Q

Why’s Polymixin not 1st line?

A

About 30% of pts develop nephrotoxicity

36
Q

What’s the drug of choice for mild to moderate C.Diff?

A

Metronidazole

37
Q

What PROTOZOAN is susceptible to metronidazole?

A

Giardia lambia
Gardinerella vaginalis
Entamoeba Histolytica

GET

38
Q

What AB has a metallic taste as a SE?

A

Metronidazole

39
Q

List atypical m.o. Covered byFluroquinolones

A

Mycoplasma
Legionella
Chlamydia
Myocobacteria including TB

40
Q

What ABs cover atypical m.o.?

A

Fluoroquinolones e.g Ciprofloxacin,
Sulfonamide
Macrolide e.g. Azithromycin, Clarithromycin,

41
Q

What AB may suppress bone marrow suppression and may be a concern in Immunosuppressed pt, cancer pt etc

A

Sulfonamides e.g. Sulfamethoxazole, Trimethoprim

42
Q

What AB has coverage over Enterococcus?

A

Vancomycin

Tigecycline

Aminoglycosides

Fluoroquinolones

43
Q

What AB are active against VRE + ALL Enterococcus?

A

Streptogramins
Tigecycline
Daptomycin
Oxazolidinones - Linezolid

44
Q

What AB are active against MRSA?

A 
Ceftaroline
Vancomycin
Tigacycline
Oxazolidinones
Daptomycin
Streptogramniss
45
Q

What AB are effective against gram tv only?

A

Glycopeptides e.g. Vancomycin
Oxazolifdinones e.g. Linezolid
Lipoprotein e.g. Daptomycin
Streptogramniss

46
Q

What AB are effective against gram -ve only?

A

Monobactam e.g. Aztreonam

Aminoglycosides

PolymixIns B + E

47
Q

What AB may cuz blood dyscrasias?

A

Chloramphenicol

Trimethoprim

DAST 7 Exam 2 (9 decks)

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