Tests for Secondary Hemostasis

Question 1

standard anticoagulant for coagulation studies

Answer 1

3.2% (0.109 M) buffered sodium citrate

Question 2

result of hematocrit, APTT & PT in polycythemic patients

Answer 2

increased

Question 3

anychanges in pH would cause the APTT and PT to be:

Answer 3

prolonged

Question 4

stable for 4 hours when properly frozen

Answer 4

fibrinogen

Question 5

normal value of clotting time in capillary/slide method

Answer 5

2-4(8) minutes

Question 6

normal value of clotting time in whole blood/tube/Lee and White method

Answer 6

5(7)-15 minutes

Question 7

appropriate test tube size for clotting time

Answer 7

12x75; 13x100

Question 8

reagent for prothrombin time

Answer 8

calcium chloride and thromboplastin

Question 9

normal value for prothrombin time

Answer 9

10-12 seconds

Question 10

ISI value that is more sensitive according to WHO

Answer 10

<1

Question 11

INR of 2.0-3.0 is recommended for:

Answer 11

most indications

Question 12

INR of 2.5 to 3.5 is indicated for:

Answer 12

patients with prosthetic heart valves

Question 13

INR of 3.0 is indicated for:

Answer 13

patients with embolism treatment

Question 14

the most sensitive PT reagent

Answer 14

Manchester reagent; derived from HUMAN BRAIN THROMBOPLASTIN

Question 15

reagent for APTT:

Answer 15

calcium chloride
phospholipid
activator: micronized silica, ellagic acid, celite and kaolin

Question 16

normal value for APTT

Answer 16

25-35 seconds

Question 17

normal value of Stypven time

Answer 17

6-10 seconds

Question 18

normal value of thrombin time AKA fibrinigen deficiency test

Answer 18

10-14 seconds or <20 seconds

Question 19

normal value of reptilase time

Answer 19

10-15 seconds

Question 20

reagent in Duckert’s test

Answer 20

5M urea

substitutes: 1% monochloroacetic acid or 2% acetic acid

Question 21

normal result for Duckert’s test

Answer 21

insoluble clot in 5M urea for 24 hours

Question 22

normal fibrinogen level:

Answer 22

200-400 mg/dl

Question 23

substances that are specific evidences of intravascular fibrin formation

Answer 23

D-DImers

Question 24

tests that measure specific fragments arising from degradation of cross-linked finrins (X,Y,D,E)

Answer 24

Latex D-Dimer test

Question 25

normal value of latex D-dimer test

Answer 25

<200 mg/dl

Question 26

this test is only sensitive to detect large amounts of fibrinolytic activity

Answer 26

whole blood clot lysis time

Question 27

test that does not detect FDP

Answer 27

euglobin clot lysis time

Question 28

euglobin fractions consists of:

Answer 28

plasminogen
plasminogen activator
fibrinogen

Question 29

the euglobin fraction of plama is separated, dissolved and allowed to clot via:

Answer 29

1% acetic acid
phosphate buffer (7.2)
thrombin

Question 30

normal value of euglobin clot lysis time

Answer 30

> 2 hours

Question 31

an intravenous anticoagulant

Answer 31

heparin

Question 32

oral anticoagulants include:

Answer 32

warfarin
coumadin
coumarin

Question 33

action of heparin

Answer 33

inhibits thrombin

Question 34

action of warfarin, coumarin and coumadin

Answer 34

inhibits vitamin K group

Question 35

heparin is neutralized by:

Answer 35

protamine sulfate

Question 36

warfarin, coumarin and coumadin are neutralized by:

Answer 36

vitamin K and FFP

Question 37

heparin is used to monitor:

Answer 37

APTT, ACT

Question 38

warfarin, coumadin and coumarin are used to monitor:

Answer 38

PT