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Primary Hemostasis Flashcards

1
Q

vasoconstriction is mediated by:

A 
serotonin (platelets)
thromboxane A2 (endothelial cells)
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2
Q

this is the first response to injured vessels

A

vasoconstriction

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3
Q

this is the property of adhering to other particles, surfaces and occasional bacteria

A

platelet adhesion

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4
Q

this attaches to GP1B

A

von Willebrand factor (factor VIII:R)

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5
Q

when activated, platelets assume this shape

A

discoid to spherical

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6
Q

factors released by damaged endothelium

A 
"FCVAT"
collagen
fibronectin
VWF
thrombin
ADP
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7
Q

these are the DENSE granules

A 
CAPAS
calcium
ADP
pyrophosphate
ATP
serotonin
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8
Q

platelet secretions that promote coagulation

A 
"HM? 158"
HMWK
fibrinogen
factor V
factor VIII
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9
Q

plate let secretions that promote aggregation

A 
"PACT"
platelet factor 4
ADP
calcium
thrombospondin
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10
Q

platelet secretions that promote vasoconstriction

A

serotonin

thromboxane A2

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11
Q

platelet secretion that promotes vascular repair

A

plate derived growth factor

B-thromboglobulin

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12
Q

platelet secretion that is the precursor of plasmin

A

plasminogen

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13
Q

platelet secretion that inhibits plasmin

A

alpha-2-antiplasmin

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14
Q

platelet secretion that inhibits the complement system

A

C1 esterase inhibitor

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15
Q

constituents that promote platelet aggregation or agglutination

A 
"TEARR"
thrombin
epinephrine
ADP
reptilase
ristocetin
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16
Q

receptor to fibrinogen

A

GPIIb-GPIIIa

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17
Q

end result is the formation of fibrin clot

A

secondary hemostasis

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18
Q

normal platelet count

A

150,000 to 440,000/mm3

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19
Q

platelet structure that consists the peripheral zone of the platelet

A

glycocalyx

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20
Q

receptor of thrombin

A

GPVa

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21
Q

platelet ultrastructure that consists of microtubules and microfilaments

A

sol-gel zone

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22
Q

responsible for the circumference of the cell

A

microtubules

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23
Q

responsible for clot retraction

A

thrombosthenin AKA actomysin

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24
Q

responsible for the direct communication between intracellular and extracellular compartments

A

open canalicular system

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25
this is the site of arachidonic acid metabolism and calcium sequestering pump
dense tubular system
26
process of nuclear splitting without cytoplasmic division
endomitosis
27
nucleus is horse shoe shaped
promegakaryoblast
28
largest cell in the bone marrow
megakaryocyte
29
1 mature megakaryocyte can yield:
2,000 to 7,000 platelets
30
normal platelet size
2-3u
31
maturation time of platelets (MATURATION= BONE MARROW)
5 days
32
number of megakaryocytes contained in a normal marrow
15 million (5-10 megakaryoctes/ LPF)
33
normal life span of platelets (LIFE SPAN=CIRCULATION)
8-10 days
34
division of the entire population of platelets
1/3 in the spleen | 2/3 in the circulation
35
splenomegaly would cause:
decreased platelet count (thrombocytopenia)
36
splenectomy would cause:
increased platelet count (thrombocytosis)
37
rebound thromboCYTOPENIA occurs after:
platelet transfusion
38
rebound thromboCYTOSIS occurs after:
platelet depletion
39
platelet count in thrombocytopenia
<100,000 platelets/mm3
40
consequence of excessive deposition of platelet aggregates in renal and cerebral vessels, deficiency in platelet aggregating factor inhibitor
thrombotic thrombocytopenic purpura
41
platelet count of a patient with ACUTE IDIOPATHIC THROMBOCYTOPENIC PURPURA
<20,000/mm3
42
platelet count of a patient with CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA
30,000 to 80,000/mm3
43
drugs that may induce idiopathic thrombocytopenic purpura
quinidine | heparin
44
platelet count in thrombocytosis
>450,000/mm3
45
disorder in GPIIb or GPIIIa and a defect in platelet aggregation
Glanzmann's thrombasthenia
46
defect in GPIb/IX complex and a defect in platelet adhesion
Bernard-Soulier syndrome
47
disease that prevents the binding of platelets to the endothelium and a defect in platelet adhesion
von Willebrand disease
48
platelet disorder with a normal platelet count
Glanzmann's thrombasthenia
49
platelet disorder with an increased mean platelet volume
Bernard-Soulier syndrome
50
disorders that FAIL to have a NORMAL AGGREGATION PATTERN but a NORMAL RISTOCETIN
Glanzmann's thrombasthenia | Bernard-Soulier syndrome
51
disorders that FAIL to have a NORMAL RISTOCETIN but a NORMAL AGGREGATION PATTERN
von Willebrand disease
52
disease characterised by decreased numbers in dense granules and has mutation in HPS1 gene
Hermansky-Pudlak syndrome
53
most definite diagnosis for Hemansky-Pudlak syndrome
electron microscope
54
disease characterised by LYST gene
Chediak-Higashi syndrome
55
disease characterised by mutation in WASP gene
Wiskott-Aldrich syndrome
56
disease characterized by marked decrease or absence of alpha granules
Grey platelet syndrome
57
classified as consumption coagulopathy due to depostion of large amounts of fibrin throughout the microcirculation
disseminated intravascular coagulation (DIC)
58
DIC caused by the extrinsic system is stimulated by:
tissue factor
59
DIC caused by the intrinsic system is stimulated by
collagen
60
disease characterized by abnormal collagen production resulting to defective basement membrane structure
Ehler-Danlos syndrome/ Marfan's syndrome
61
disease characterzed by progeressive calcification and fragmentation of elastic fibers of the skin
pseudoxanthoma elasticum
62
most common hereditary alterations of vessel wall syndrome that causes blood vessels to become fragile, and thin
hemorrhagic telangietasia
63
disease characterized by a blood vessel tumor
congenital hemagiomata
64
disease characterized by defective collagen synthesis due to deficiency in VItamin C
scurvy
65
characterized by localized purple lesions or small bruises developing on the extremities of older persons
senile purpura
66
autoimmune vascular purpura with gastrointestinal involvement
Henoch's purpura
67
autoimmune vascular purpura without gastrointestinal involvement
Schonlein purpura

Hematology (5 decks)

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