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Hematology > Secondary Hemostasis > Flashcards

Secondary Hemostasis Flashcards

1
Q

preferred name and synonyms of factor I

A

fibrinogen

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2
Q

preferred name and synonyms of factor II

A

prothrombin

prethrombin

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3
Q

preferred name and synonyms of factor III

A

tissue factor
tissue thromboplastin
*thrombokinase

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4
Q

preferred name and synonyms of factor IV

A

calcium

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5
Q

preferred name and synonyms of factor V

A

proaccelerin
labile factor
accelerator globulin
*thrombogen

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6
Q

preferred name and synonyms of factor VII

A 
proconvertin
stable factor
autoprothrombin 1
*cothromboplastin
*serum prothrombin conversion accelerator
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7
Q

preferred name and synonyms of factor VIII

A 
antihemophilic factor
antihemophilic globulin
antihemophilic factor A
platelet cofactor 1
*thromboplastinigen
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8
Q

preferred name and synonyms of factor IX

A 
antihemophilic factor B
autoprothrombin 2
platelet cofactor 2
Christmas factor
plasma thromboplastin component (PTC)
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9
Q

preferred name and synonyms of factor X

A

Stuart factor
Prower factor
Stuart-Prower factor
autoprothrombin 3

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10
Q

preferred name and synonyms of factor XI

A

antihemophilic factor C

plasma thromboplastin antecedent (PTA)

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11
Q

preferred name and synonyms of factor XII

A

Hageman factor
glass factor
contact factor

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12
Q

preferred name and synonyms of factor XIII

A 
Laki-Lorand factor
fibrin stabilizing factor
*fibrinase
*fibrinoligase
*plasma transglutaminase
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13
Q

preferred name and synonyms of prekalikrein

A

Fletcher factor

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14
Q

preferred name and synonyms of HMWK

A

Fitzgerald factor
contact activation factor
Williams factor
Flaujeuc factor

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15
Q

a transglutaminase

A

factor XIII

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16
Q

factors that are labile in room temperature

A

factor V and VIII

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17
Q

factors that are cold labile

A

factor VII and XI

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18
Q

intrinsic pathway factors

A

factors XII, XI, HMWK and prekalikrein

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19
Q

extrinsic pathway factors

A

factor VII

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20
Q

common pathway factors

A

factors I, II, V, X

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21
Q

factors that are affected by oral anticoagulants such as coumarin, coumadin and warfarin

A

“Vitamin K dependent/Prothrombin group”
factors II, VII, IX, X
protein S and protein C

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22
Q

coagulation factors that are consumed first in coagulation

A

“Fibrinogen group”

factors I, V, VIII, XIII

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23
Q

coagulation factors that are considered as acute phase reactants

A

“Fibrinogen group”

factors I, V, VIII, XIII

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24
Q

the active enzyme of fibrinolysis that dissolves FIBRIN, FIBRINOGEN, FACTOR V, FACTOR VIII and also activates complement

A

plasmin

25
Q

these are the plasminogen activators

A

factor XIIa, kallikrien, HMWK, plasma proactivator

26
Q

substances that act BOTH as INHIBITORS of COAGULATION and FIBRINOLYSIS

A

a-2-macroglobulin: thrombin, kallikrien, plasmin
a-1-antitrypsin: thrombin, Xa, XIa, plasmin
C1 inhibitor: kallikrein, XIIa, plasmin

27
Q

inhibitors of coagulation that degrades factor V and VIII

A

protein S and protein C

28
Q

inhibitors of thrombin

A 
antithrombin III (major inhibitor)
heparin cofactor II
29
Q

inhibits factor VIIa tissue factor complex

A

extrinsic pathway inhibitor or lipoprotein associated coagulation inhibitor (LACI)

30
Q

major inhibitor of plasmin

A

a-2-antiplasmin

31
Q

FDPs that are early degradation products; have anticoagulant activity

A

X and Y

32
Q

FDPs that are late degradation products

A

D and E

33
Q

FDPs that inhibit fibrin polymerization

A

Y and D

34
Q

FDP that is a powerful inhibitor of thrombin

A

E

35
Q

pathologic fibrinolysis characterized by the degradation of fibrinogen

A

primary fibrinolysis

36
Q

pathologic fibrinolysis characterized by the degradation of fibrin

A

secondary fibrinolysis

37
Q

test to differentiate primary fibrinolysis ans secondary fibrinolysis

A

protamine sulfate test

primary: negative
secondary: positive

38
Q

when does primary fibrinolysis happen?

A

excessive amount of plasminogen actovators

39
Q

when does secondary fibrinolysis happen?

A

DIC, snake bites, neoplasm and snake bites

40
Q

laboratory findings of qualitative and quantitative deficiencies of FIBRINOGEN

A

APTT, PT, TT: PROLONGED

41
Q

treatment for afibrinogenemia

A

cryoprecipitate, FFP

42
Q

laboratory findings in dysfibrinogenemia

A

NORMAL bleeding time, and unusually normal levels of fibrinogen that are however non/dysfunctional

43
Q

laboratory findings in factor XIII deficiency

A

APTT, PT, TT: NORMAL

44
Q

test that is never affected by heparin

A

reptilase time

45
Q

other name for factor XI deficiency

A

Rosenthal syndrome

46
Q

other name for factor V deficiency

A

parahemophilia, Owren’s disease

47
Q

acquired disorders of factor XIII can be caused by:

A

isoniazid

48
Q

acquired disorders of factor X can be caused by:

A

amyloidosis

49
Q

the lupus-like inhibitor may be acquired thru:

A

SLE

phenazothiazine

50
Q

synergistic activity of these two substances would enhance the ability to bind and inactivate thrombin; also used to TREAT THROMBOSIS

A

heparin and antithrombin III

51
Q

substance that neutralizes heparin

A

protamine sulfate

52
Q

hereditary pattern of all coagulation factors except factor I and factor VIII

A

autosomal recessive

53
Q

hereditary pattern of factor I and factor VIII

A

autosomal dominant

54
Q

abnormality in bleeding time is caused by:

A

disease of primary hemostasis

von Willebrand disease

55
Q

abnormality in PT is caused by:

A

abnormality in extrinsic and common pathway

56
Q

abnormality in APTT is caused by:

A

abnormality in intrinsic and common pathway

57
Q

abnormality in stypven time is caused by:

A

factors I, II, V, X deficiency

58
Q

abnormality in thrombin time is caused by:

A

factor I deficiency

59
Q

abnormality in Duckert’s test is caused by:

A

factor XIII deficiency

Hematology (5 decks)

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