Secondary Hemostasis

Question 1

preferred name and synonyms of factor I

Answer 1

fibrinogen

Question 2

preferred name and synonyms of factor II

Answer 2

prothrombin

prethrombin

Question 3

preferred name and synonyms of factor III

Answer 3

tissue factor
tissue thromboplastin
*thrombokinase

Question 4

preferred name and synonyms of factor IV

Answer 4

calcium

Question 5

preferred name and synonyms of factor V

Answer 5

proaccelerin
labile factor
accelerator globulin
*thrombogen

Question 6

preferred name and synonyms of factor VII

Answer 6

proconvertin
stable factor
autoprothrombin 1
*cothromboplastin
*serum prothrombin conversion accelerator

Question 7

preferred name and synonyms of factor VIII

Answer 7

antihemophilic factor
antihemophilic globulin
antihemophilic factor A
platelet cofactor 1
*thromboplastinigen

Question 8

preferred name and synonyms of factor IX

Answer 8

antihemophilic factor B
autoprothrombin 2
platelet cofactor 2
Christmas factor
plasma thromboplastin component (PTC)

Question 9

preferred name and synonyms of factor X

Answer 9

Stuart factor
Prower factor
Stuart-Prower factor
autoprothrombin 3

Question 10

preferred name and synonyms of factor XI

Answer 10

antihemophilic factor C

plasma thromboplastin antecedent (PTA)

Question 11

preferred name and synonyms of factor XII

Answer 11

Hageman factor
glass factor
contact factor

Question 12

preferred name and synonyms of factor XIII

Answer 12

Laki-Lorand factor
fibrin stabilizing factor
*fibrinase
*fibrinoligase
*plasma transglutaminase

Question 13

preferred name and synonyms of prekalikrein

Answer 13

Fletcher factor

Question 14

preferred name and synonyms of HMWK

Answer 14

Fitzgerald factor
contact activation factor
Williams factor
Flaujeuc factor

Question 15

a transglutaminase

Answer 15

factor XIII

Question 16

factors that are labile in room temperature

Answer 16

factor V and VIII

Question 17

factors that are cold labile

Answer 17

factor VII and XI

Question 18

intrinsic pathway factors

Answer 18

factors XII, XI, HMWK and prekalikrein

Question 19

extrinsic pathway factors

Answer 19

factor VII

Question 20

common pathway factors

Answer 20

factors I, II, V, X

Question 21

factors that are affected by oral anticoagulants such as coumarin, coumadin and warfarin

Answer 21

“Vitamin K dependent/Prothrombin group”
factors II, VII, IX, X
protein S and protein C

Question 22

coagulation factors that are consumed first in coagulation

Answer 22

“Fibrinogen group”

factors I, V, VIII, XIII

Question 23

coagulation factors that are considered as acute phase reactants

Answer 23

“Fibrinogen group”

factors I, V, VIII, XIII

Question 24

the active enzyme of fibrinolysis that dissolves FIBRIN, FIBRINOGEN, FACTOR V, FACTOR VIII and also activates complement

Answer 24

plasmin

Question 25

these are the plasminogen activators

Answer 25

factor XIIa, kallikrien, HMWK, plasma proactivator

Question 26

substances that act BOTH as INHIBITORS of COAGULATION and FIBRINOLYSIS

Answer 26

a-2-macroglobulin: thrombin, kallikrien, plasmin a-1-antitrypsin: thrombin, Xa, XIa, plasmin C1 inhibitor: kallikrein, XIIa, plasmin

Question 27

inhibitors of coagulation that degrades factor V and VIII

Answer 27

protein S and protein C

Question 28

inhibitors of thrombin

Answer 28

``` antithrombin III (major inhibitor) heparin cofactor II ```

Question 29

inhibits factor VIIa tissue factor complex

Answer 29

extrinsic pathway inhibitor or lipoprotein associated coagulation inhibitor (LACI)

Question 30

major inhibitor of plasmin

Answer 30

a-2-antiplasmin

Question 31

FDPs that are early degradation products; have anticoagulant activity

Answer 31

X and Y

Question 32

FDPs that are late degradation products

Answer 32

D and E

Question 33

FDPs that inhibit fibrin polymerization

Answer 33

Y and D

Question 34

FDP that is a powerful inhibitor of thrombin

Answer 34

E

Question 35

pathologic fibrinolysis characterized by the degradation of fibrinogen

Answer 35

primary fibrinolysis

Question 36

pathologic fibrinolysis characterized by the degradation of fibrin

Answer 36

secondary fibrinolysis

Question 37

test to differentiate primary fibrinolysis ans secondary fibrinolysis

Answer 37

protamine sulfate test primary: negative secondary: positive

Question 38

when does primary fibrinolysis happen?

Answer 38

excessive amount of plasminogen actovators

Question 39

when does secondary fibrinolysis happen?

Answer 39

DIC, snake bites, neoplasm and snake bites

Question 40

laboratory findings of qualitative and quantitative deficiencies of FIBRINOGEN

Answer 40

APTT, PT, TT: PROLONGED

Question 41

treatment for afibrinogenemia

Answer 41

cryoprecipitate, FFP

Question 42

laboratory findings in dysfibrinogenemia

Answer 42

NORMAL bleeding time, and unusually normal levels of fibrinogen that are however non/dysfunctional

Question 43

laboratory findings in factor XIII deficiency

Answer 43

APTT, PT, TT: NORMAL

Question 44

test that is never affected by heparin

Answer 44

reptilase time

Question 45

other name for factor XI deficiency

Answer 45

Rosenthal syndrome

Question 46

other name for factor V deficiency

Answer 46

parahemophilia, Owren's disease

Question 47

acquired disorders of factor XIII can be caused by:

Answer 47

isoniazid

Question 48

acquired disorders of factor X can be caused by:

Answer 48

amyloidosis

Question 49

the lupus-like inhibitor may be acquired thru:

Answer 49

SLE | phenazothiazine

Question 50

synergistic activity of these two substances would enhance the ability to bind and inactivate thrombin; also used to TREAT THROMBOSIS

Answer 50

heparin and antithrombin III

Question 51

substance that neutralizes heparin

Answer 51

protamine sulfate

Question 52

hereditary pattern of all coagulation factors except factor I and factor VIII

Answer 52

autosomal recessive

Question 53

hereditary pattern of factor I and factor VIII

Answer 53

autosomal dominant

Question 54

abnormality in bleeding time is caused by:

Answer 54

disease of primary hemostasis | von Willebrand disease

Question 55

abnormality in PT is caused by:

Answer 55

abnormality in extrinsic and common pathway

Question 56

abnormality in APTT is caused by:

Answer 56

abnormality in intrinsic and common pathway

Question 57

abnormality in stypven time is caused by:

Answer 57

factors I, II, V, X deficiency

Question 58

abnormality in thrombin time is caused by:

Answer 58

factor I deficiency

Question 59

abnormality in Duckert's test is caused by:

Answer 59

factor XIII deficiency