Secondary Hemostasis Flashcards
preferred name and synonyms of factor I
fibrinogen
preferred name and synonyms of factor II
prothrombin
prethrombin
preferred name and synonyms of factor III
tissue factor
tissue thromboplastin
*thrombokinase
preferred name and synonyms of factor IV
calcium
preferred name and synonyms of factor V
proaccelerin
labile factor
accelerator globulin
*thrombogen
preferred name and synonyms of factor VII
proconvertin stable factor autoprothrombin 1 *cothromboplastin *serum prothrombin conversion accelerator
preferred name and synonyms of factor VIII
antihemophilic factor antihemophilic globulin antihemophilic factor A platelet cofactor 1 *thromboplastinigen
preferred name and synonyms of factor IX
antihemophilic factor B autoprothrombin 2 platelet cofactor 2 Christmas factor plasma thromboplastin component (PTC)
preferred name and synonyms of factor X
Stuart factor
Prower factor
Stuart-Prower factor
autoprothrombin 3
preferred name and synonyms of factor XI
antihemophilic factor C
plasma thromboplastin antecedent (PTA)
preferred name and synonyms of factor XII
Hageman factor
glass factor
contact factor
preferred name and synonyms of factor XIII
Laki-Lorand factor fibrin stabilizing factor *fibrinase *fibrinoligase *plasma transglutaminase
preferred name and synonyms of prekalikrein
Fletcher factor
preferred name and synonyms of HMWK
Fitzgerald factor
contact activation factor
Williams factor
Flaujeuc factor
a transglutaminase
factor XIII
factors that are labile in room temperature
factor V and VIII
factors that are cold labile
factor VII and XI
intrinsic pathway factors
factors XII, XI, HMWK and prekalikrein
extrinsic pathway factors
factor VII
common pathway factors
factors I, II, V, X
factors that are affected by oral anticoagulants such as coumarin, coumadin and warfarin
“Vitamin K dependent/Prothrombin group”
factors II, VII, IX, X
protein S and protein C
coagulation factors that are consumed first in coagulation
“Fibrinogen group”
factors I, V, VIII, XIII
coagulation factors that are considered as acute phase reactants
“Fibrinogen group”
factors I, V, VIII, XIII
the active enzyme of fibrinolysis that dissolves FIBRIN, FIBRINOGEN, FACTOR V, FACTOR VIII and also activates complement
plasmin
these are the plasminogen activators
factor XIIa, kallikrien, HMWK, plasma proactivator
substances that act BOTH as INHIBITORS of COAGULATION and FIBRINOLYSIS
a-2-macroglobulin: thrombin, kallikrien, plasmin
a-1-antitrypsin: thrombin, Xa, XIa, plasmin
C1 inhibitor: kallikrein, XIIa, plasmin
inhibitors of coagulation that degrades factor V and VIII
protein S and protein C
inhibitors of thrombin
antithrombin III (major inhibitor) heparin cofactor II
inhibits factor VIIa tissue factor complex
extrinsic pathway inhibitor or lipoprotein associated coagulation inhibitor (LACI)
major inhibitor of plasmin
a-2-antiplasmin
FDPs that are early degradation products; have anticoagulant activity
X and Y
FDPs that are late degradation products
D and E
FDPs that inhibit fibrin polymerization
Y and D
FDP that is a powerful inhibitor of thrombin
E
pathologic fibrinolysis characterized by the degradation of fibrinogen
primary fibrinolysis
pathologic fibrinolysis characterized by the degradation of fibrin
secondary fibrinolysis
test to differentiate primary fibrinolysis ans secondary fibrinolysis
protamine sulfate test
primary: negative
secondary: positive
when does primary fibrinolysis happen?
excessive amount of plasminogen actovators
when does secondary fibrinolysis happen?
DIC, snake bites, neoplasm and snake bites
laboratory findings of qualitative and quantitative deficiencies of FIBRINOGEN
APTT, PT, TT: PROLONGED
treatment for afibrinogenemia
cryoprecipitate, FFP
laboratory findings in dysfibrinogenemia
NORMAL bleeding time, and unusually normal levels of fibrinogen that are however non/dysfunctional
laboratory findings in factor XIII deficiency
APTT, PT, TT: NORMAL
test that is never affected by heparin
reptilase time
other name for factor XI deficiency
Rosenthal syndrome
other name for factor V deficiency
parahemophilia, Owren’s disease
acquired disorders of factor XIII can be caused by:
isoniazid
acquired disorders of factor X can be caused by:
amyloidosis
the lupus-like inhibitor may be acquired thru:
SLE
phenazothiazine
synergistic activity of these two substances would enhance the ability to bind and inactivate thrombin; also used to TREAT THROMBOSIS
heparin and antithrombin III
substance that neutralizes heparin
protamine sulfate
hereditary pattern of all coagulation factors except factor I and factor VIII
autosomal recessive
hereditary pattern of factor I and factor VIII
autosomal dominant
abnormality in bleeding time is caused by:
disease of primary hemostasis
von Willebrand disease
abnormality in PT is caused by:
abnormality in extrinsic and common pathway
abnormality in APTT is caused by:
abnormality in intrinsic and common pathway
abnormality in stypven time is caused by:
factors I, II, V, X deficiency
abnormality in thrombin time is caused by:
factor I deficiency
abnormality in Duckert’s test is caused by:
factor XIII deficiency
