Leukocytes (Leukopoiesis, Leukemia, other Diseases)

Question 1

normal M:E ratio

Answer 1

3:1 (2:1 to 4:1)

Question 2

days of maturation (IN THE BONE MARROW) of leukocytes

Answer 2

14 days

Question 3

start of the formation of primary granules

Answer 3

promyelocyte

Question 4

start of the formation of secondary granules

Answer 4

myelocyte

Question 5

WBC precursor that has an indented kidney shaped nucleus

Answer 5

metamyelocyte

Question 6

primary granules

Answer 6

“Cats Are My Elastics to Acids”

cationic antibacterial proteins
arylsulfatse
myeloperoxidase
elastase
acid phosphatase
acid hydrolase

Question 7

WBC precursor that has the highest number in the bone marrow

Answer 7

metamyelocyte/juvenile cells

Question 8

secondary granules specific to neutrophils

Answer 8

“CALL”

collagenase
alkaline phosphatase
lyzozyme
lactoferrin

Question 9

secondary granules specific to eosinophls

Answer 9

major basic proteins

Question 10

secondary granules specific to basophils

Answer 10

heparin

histamine

Question 11

random locomotion is AKA

Answer 11

chemoKINESIS

Question 12

directed locomotion is AKA

Answer 12

chemoTAXIS

Question 13

neutrophil enzyme responsible for respiratory burst or oxidative burst

Answer 13

myeloperoxidase

Question 14

neutrophil enzyme that degrades the bacterial cell wall

Answer 14

lyzozyme or muramidase

Question 15

neutrophil enzyme that competes with bacteria for iron

Answer 15

lactoferrin

Question 16

neutrophil life span (IN THE CIRCULATION)

Answer 16

9-10 days

Question 17

major function of basophils

Answer 17

hypersensitivity reactions such as allergic asthma and delayed hypersensitivity reaction

Question 18

granule responsible for the metachromicity of basophils

Answer 18

heparin

Question 19

granules that mediate hypersensitivity reaction

Answer 19

histamine

Question 20

WBC that is metabolically more active than the neutrophil

Answer 20

eosinophil

Question 21

an increase in ACTH would cause:

Answer 21

decreased eosinophil count

Question 22

functions of major basic proteins

Answer 22

against helminths
neutralize histamine
neutralize heparin
induce heparin

Question 23

test that will evaluate normal adrenal function

Answer 23

Thorn’s test/eosinophil depression test

Question 24

sample collection for Thorn’s test

Answer 24

1) Basal state
2) 4 hours after ACTH administration
3) compared values

Question 25

normal values of Thorn’s test

Answer 25

ACTH should DECREASE eosinophil count by 50%

> 50%: Cushing’s (HYPER)
<50%: Addison/s (HYPO)

Question 26

largest cell in the peripheral blood

Answer 26

monocyte

Question 27

size of a macrophage

Answer 27

15-80 um

Question 28

CD markers of T cells

Answer 28

CD2, CD4, CD8

Question 29

CD markers of B cells

Answer 29

CD10, CD19, CD24

Question 30

CD markers of null lymphocyte

Answer 30

CD16, CD56, CD94

Question 31

appearance of plasmacytes

Answer 31

nucleus: cartwheel
cytoplasm: perinuclear hoff

Question 32

WBC count in granulocytosis

Answer 32

> 10,000/mm3 (>11,000/mm3)

Question 33

WBC count in granulocytopenia

Answer 33

<3,000/mm3

Question 34

count in eosinophilia

Answer 34

> 400/mm3

Question 35

count in basophilia

Answer 35

> 40/mm3

Question 36

count in monocytosis

Answer 36

> 800/mm3