TESTS FOR DETOXIFICATION FUNCTION Flashcards
T/F. TESTS FOR DETOXIFICATION FUNCTION, Involves enzymes and ammonia test
True
TESTS FOR DETOXIFICATION FUNCTION
Enzyme Tests
Ammonia
Glutamate Dehydrogenase
It is used to assess the extent of liver damage
Enzyme Tests
Indicator of cell injury in early or localized liver disease (hepatocellular/functional disease)
Enzyme Tests
T/F. Enzymes are heated intracellular. if there’s liver damage, enzymes are liberated in the hepatocytes and increase in the circulation. This may suggests that the patient has liver damage
True
Hepatic enzymes: (enzymes used to assess hepatic damage)
o Alanine transaminase (ALT)
o Aspartate aminotransferase (AST)
o 5’ nucleotidase
o Gamma-glutamyl transferase (GGT)
o Ornithine Carbamoyltransferase (OCT)
produced by deamination of amino acids
Ammonia
Proteolysis of protein which is principally enzymatic (long chain of amino acid bind by peptide bond) → Amino Acids → undergo transamination and oxidative deamination → ammonia → enzymatic synthesis in the urea cycle or Krebs Henseleit cycle which occurs in the liver → urea → excreted in the urine
Protein Metabolism (Normal condition)
T/F. If you have hepatic problem, the normal cycle will not happen therefore, ammonia will not be converted to urea
true
Increase ammonia =
neurotoxic
T/F. If ammonia is not converted to urea, glutamate will be produced → high glutamate → coma
True
- Diagnostic marker of hepatic failure
- Detoxified into urea (liver), then eliminated by the kidneys (urine)
Ammonia
Ammonia Reference value:
19-60 ug/dL
Ammonia Preferred sample:
Venous blood or Plasma
by using the following anticoagulant
Heparin, EDTA, potassium oxalate
