TESTS FOR CONJUGATION AND EXCRETION FUNCTION Flashcards
No physiologic function only a WASTE PRODUCT
which is dapat tinatapon!!! Excreted!!!!
BILIRUBIN
Conjugated which is excreted in the liver
Bilirubin
End product of hemoglobin metabolism
BILIRUBIN
containing proteins such as myoglobin, catalase
and cytochrome oxidase.
Also formed from destruction of heme
85% of the bilirubin
Heme
Other heme containing proteins
15%
Plasma concentration of bilirubin increases upon
birth and reaches its peak on ?
5th day
If bilirubin synthesis > liver clearance rate = ?
INCREASE BILIRUBIN LEVEL
Reference Value :
0-0.2 mg/dL (0-3 µmol/L)
Conjugated bilirubin
Reference Value :
0.2-0.8 mg/dL (3-14
µmol/L)
Unconjugated bilirubin
Reference Value :
0.2-1.0 mg/dL (3-17 µmol/L)
Total bilirubin
Flowchart
will release hemoglobin.
Senescent RBC
Flowchart
consist of iron, heme, globin
Hemoglobin
Flowchart
transported by transferrin to the bone
marrow and inside the cell
Iron
Flowchart
degraded to amino acid-> reuse
Globin
Flowchart
converted to biliverdin by heme oxygenase
Heme
Flowchart
converted by biliverdin
reductase
BILIVERDIN-> BILIRUBIN B1
Flowchart
water insoluble; nonpolar bilirubin;
hemobilirubin
BILIRUBIN B1
Flowchart
Also called ___________ found and
synthesized in the circulation
Hemobilirubin
Flowchart
bilirubin formed before it
reached the level
Prehepatic
Flowchart
it should be conjugate
located in the liver which is also called unconjugated bilirubin
Bilirubin 1 to be excreted-
Flowchart
attached to the albumin-> which will go
to the liver -> it will go to the ligandins -> hepatocytes
which conjugation occur = bilirubin 1 converted to
bilirubin monocolglucoronide AND
DIGGLUCORONIDE (B2) through the action of
“UDGPT” URIDINE DIPHOSPHATE GLUCORONYL/
GLUCORONOSYL TRANSFERASE
Bilirubin 1
Flowchart
from the liver –> hepatic duct combine
to the secretion from the gallbladder-> common bile
duct -> intestine (b2 will reduce by intestinal flora) =
mesobilinogen-> urobilinogen
BILIRUBIN 2
Flowchart
not normally present in the circulation in
the blood because it is secrete to liver and go to the
intestine ; but small amount may leak into circulation
but normally 0
Bilirubin 2
Flowchart
normally present in the circulation of
blood
Bilirubin 1
Flowchart
Urobilinogen synthesized 2 phased
___ - will converted into stercobilinogen ->
stercobilin ( orange colored product) -
excrete in stool= brown color
80%
Flowchart
Urobilinogen synthesized 2 phased
___ - reabsorbed in the liver which is
recycled and reexcreted in the urine in the
form of UROBILIN (PRINCIPAL PRODUCTS
WHICH GIVES URINE COLOR)
20%
