TESTS FOR CONJUGATION AND EXCRETION FUNCTION

Question 1

No physiologic function only a WASTE PRODUCT
which is dapat tinatapon!!! Excreted!!!!

Answer 1

BILIRUBIN

Question 2

Conjugated which is excreted in the liver

Answer 2

Bilirubin

Question 3

End product of hemoglobin metabolism

Answer 3

BILIRUBIN

Question 4

containing proteins such as myoglobin, catalase
and cytochrome oxidase.

Answer 4

Also formed from destruction of heme

Question 5

85% of the bilirubin

Answer 5

Heme

Question 6

Other heme containing proteins

Answer 6

15%

Question 7

Plasma concentration of bilirubin increases upon
birth and reaches its peak on ?

Answer 7

5th day

Question 8

If bilirubin synthesis > liver clearance rate = ?

Answer 8

INCREASE BILIRUBIN LEVEL

Question 9

Reference Value :

0-0.2 mg/dL (0-3 µmol/L)

Answer 9

Conjugated bilirubin

Question 10

Reference Value :

0.2-0.8 mg/dL (3-14
µmol/L)

Answer 10

Unconjugated bilirubin

Question 11

Reference Value :

0.2-1.0 mg/dL (3-17 µmol/L)

Answer 11

Total bilirubin

Question 12

Flowchart

will release hemoglobin.

Answer 12

Senescent RBC

Question 13

Flowchart

consist of iron, heme, globin

Answer 13

Hemoglobin

Question 14

Flowchart

transported by transferrin to the bone
marrow and inside the cell

Answer 14

Iron

Question 15

Flowchart

degraded to amino acid-> reuse

Answer 15

Globin

Question 16

Flowchart

converted to biliverdin by heme oxygenase

Answer 16

Heme

Question 17

Flowchart

converted by biliverdin
reductase

Answer 17

BILIVERDIN-> BILIRUBIN B1

Question 18

Flowchart

water insoluble; nonpolar bilirubin;
hemobilirubin

Answer 18

BILIRUBIN B1

Question 19

Flowchart

Also called ___________ found and
synthesized in the circulation

Answer 19

Hemobilirubin

Question 20

Flowchart

bilirubin formed before it
reached the level

Answer 20

Prehepatic

Question 21

Flowchart

it should be conjugate
located in the liver which is also called unconjugated bilirubin

Answer 21

Bilirubin 1 to be excreted-

Question 22

Flowchart

attached to the albumin-> which will go
to the liver -> it will go to the ligandins -> hepatocytes
which conjugation occur = bilirubin 1 converted to
bilirubin monocolglucoronide AND
DIGGLUCORONIDE (B2) through the action of
“UDGPT” URIDINE DIPHOSPHATE GLUCORONYL/
GLUCORONOSYL TRANSFERASE

Answer 22

Bilirubin 1

Question 23

Flowchart

from the liver –> hepatic duct combine
to the secretion from the gallbladder-> common bile
duct -> intestine (b2 will reduce by intestinal flora) =
mesobilinogen-> urobilinogen

Answer 23

BILIRUBIN 2

Question 24

Flowchart

not normally present in the circulation in
the blood because it is secrete to liver and go to the
intestine ; but small amount may leak into circulation
but normally 0

Answer 24

Bilirubin 2

Question 25

Flowchart

normally present in the circulation of
blood

Answer 25

Bilirubin 1

Question 26

Flowchart

Urobilinogen synthesized 2 phased

___ - will converted into stercobilinogen ->
stercobilin ( orange colored product) -
excrete in stool= brown color

Answer 26

80%

Question 27

Flowchart

Urobilinogen synthesized 2 phased

___ - reabsorbed in the liver which is
recycled and reexcreted in the urine in the
form of UROBILIN (PRINCIPAL PRODUCTS
WHICH GIVES URINE COLOR)

Answer 27

20%