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MDL 216 Blood Bank > Test 3A > Flashcards

Test 3A Flashcards

1
Q

Blood group MNSs is referred to as

A

Mary and Nancy

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2
Q

MNS Blood Group

What is the phenotype of MM and its frequency?

A

M

28%

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3
Q

MNS Blood Group

What is the phenotype of MN and its frequency?

A

MN

50%

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4
Q

MNS Blood Group

What is the phenotype of NN and its frequency?

A

N

22%

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5
Q

Describe warm reactive antibodies

A 
IgG
Exposure
HDN
HTR
Significant
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6
Q

Describe cold reactive antibodies

A 
IgM
Natural
No HDN
No HTR
Insignificant
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7
Q

MNS Blood Group

MN antibodies reaction temp

A

Room temperature and lower

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8
Q

MNS Blood Group

MN antibodies fixes complements

A

No

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9
Q

MNS Blood Group

MN antibodies best pH

A

anti-M at 6.5

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10
Q

MNS Blood Group

Are MN antibodies destroyed by enzymes?

A

Yes

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11
Q

MNS Blood Group

Where is anti-M observed?

A

Immediate Spin

Room Temp and colder

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12
Q

MNS Blood Group

Where is anti-N observed?

A

Immediate Spin

Room Temp and colder

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13
Q

MNS Blood Group

What are the antigens in MNSs group?

A 
M
N
U
S
s
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14
Q 
MNS Blood Group
What Ig class are S antibodies in?
A

IgG

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15
Q

MNS Blood Group

What is the best reaction temp for MNS S antibodies?

A

AHG some can be at 37C

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16
Q

MNS Blood Group

Do S antibodies fixes complement

A

Yes

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17
Q

MNS Blood Group

MN antibodies Ig class

A

Most cold reactive IgM, few IgG

18
Q

MNS Blood Group

Are MN antibodies implicated in HDFN and HTR?

A

rare

19
Q

MNS Blood Group

Does the dosage effect work with MN antibodies?

A

Yes

20
Q

MNS Blood Group

Are S antibodies implicated in HDFN and HTR?

A

Severe HTR, yes HDFN

21
Q

MNS Blood Group

Are S antibodies affected by the dosage effect?

A

No

22
Q

MNS Blood Group

Are S antibodies destroyed by enzymes?

A 
S yes (ficin & papain)
s maybe
23
Q

MNS Blood Group

What is the formation of anti-U?

A

formed S-s-U in individuals

24
Q

MNS Blood Group

Is anti-U implicated in HDFN and HTR?

A

yes

Also N-U-patients form anti”N” must receive M+N-S-s-U

25
Q

P Blood Group System

Name the 3 main P system antigens

A

P
P1
PK

26
Q

P Blood Group System

Name the 2 Blood group systems related to the P system

A

ABH and I

27
Q 
P Blood Group System
What Ig class are P antibodies?
A

IgM

28
Q

P Blood Group System

What is the best reaction temp and medium for P antibodies?

A

Room Temp and below, Saline

29
Q

P Blood Group System

Do P antibodies Fix complement

A

Yes

30
Q

P Blood Group System

Are P antibodies implicated in HDFN and HTR?

A

No

31
Q

P Blood Group System

What disease/condition is associated with Anti-P

A

Paroxysmal cold hemoglobinuria

32
Q

P Blood Group System

What disease/condition is associated with Anti-P1

A

Parasitic infections

33
Q

P Blood Group System

What disease/condition is associated with Anti P1Pk?

A

Spontaneous Abortion in early pregnancy

34
Q

P Blood Group System

Individuals lacking P system Ag’s appear to be naturally resistant to infection from _____?

A

uropathogenic E. coli, parvo-B19 virus

35
Q

P Blood Group System

Describe the effect of storage on the P antigen?

A

Rapid deterioration

36
Q

Lutheran Blood Group

What are the 2 main antigens in the Lutheran system and their frequency?

A 
Lua+ = 8%
Lub+ = 99.8%
37
Q

Lutheran Blood Group

What is the difference between anti-Lua and anti-Lub?

A

Anti-Lua is seen occasionally, but anti-Lub is very rare as most people are positive (high frequency Ag). Anti-Lua mixed field reaction

38
Q 
Lutheran Blood Group
What is the Ig class for Lutheran?
A

IgM or IgG for Lua

IgG for Lub

39
Q

Lutheran Blood Group

What is the best reaction temp and medium?

A

Room temp and below, or 37 and AHG

40
Q

Lutheran Blood Group

fixes complement?

A

Yes some

41
Q

Lutheran Blood Group

Implicated in HDFN and HTR?

A

Mild since Ag’s poorly developed at birth; mild HTR

42
Q

Kell Blood Group System

Identify the name and symbol for each of the 3 pairs of alleles in the Kell system:

A 
K - Kell 9%+
k - Cellano 99.8% +
Kpa - Penney - 2% Caucasians
Kpb - Rautenberg > 99.9%+
Jsa - Sutter 20% Black
Jsb - Matthews >99%+

MDL 216 Blood Bank (5 decks)

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