Test 3A

Question 1

Blood group MNSs is referred to as

Answer 1

Mary and Nancy

Question 2

MNS Blood Group

What is the phenotype of MM and its frequency?

Answer 2

M

28%

Question 3

MNS Blood Group

What is the phenotype of MN and its frequency?

Answer 3

MN

50%

Question 4

MNS Blood Group

What is the phenotype of NN and its frequency?

Answer 4

N

22%

Question 5

Describe warm reactive antibodies

Answer 5

IgG
Exposure
HDN
HTR
Significant

Question 6

Describe cold reactive antibodies

Answer 6

IgM
Natural
No HDN
No HTR
Insignificant

Question 7

MNS Blood Group

MN antibodies reaction temp

Answer 7

Room temperature and lower

Question 8

MNS Blood Group

MN antibodies fixes complements

Answer 8

No

Question 9

MNS Blood Group

MN antibodies best pH

Answer 9

anti-M at 6.5

Question 10

MNS Blood Group

Are MN antibodies destroyed by enzymes?

Answer 10

Yes

Question 11

MNS Blood Group

Where is anti-M observed?

Answer 11

Immediate Spin

Room Temp and colder

Question 12

MNS Blood Group

Where is anti-N observed?

Answer 12

Immediate Spin

Room Temp and colder

Question 13

MNS Blood Group

What are the antigens in MNSs group?

Answer 13

M
N
U
S
s

Question 14

MNS Blood Group
What Ig class are S antibodies in?

Answer 14

IgG

Question 15

MNS Blood Group

What is the best reaction temp for MNS S antibodies?

Answer 15

AHG some can be at 37C

Question 16

MNS Blood Group

Do S antibodies fixes complement

Answer 16

Yes

Question 17

MNS Blood Group

MN antibodies Ig class

Answer 17

Most cold reactive IgM, few IgG

Question 18

MNS Blood Group

Are MN antibodies implicated in HDFN and HTR?

Answer 18

rare

Question 19

MNS Blood Group

Does the dosage effect work with MN antibodies?

Answer 19

Yes

Question 20

MNS Blood Group

Are S antibodies implicated in HDFN and HTR?

Answer 20

Severe HTR, yes HDFN

Question 21

MNS Blood Group

Are S antibodies affected by the dosage effect?

Answer 21

No

Question 22

MNS Blood Group

Are S antibodies destroyed by enzymes?

Answer 22

S yes (ficin & papain)
s maybe

Question 23

MNS Blood Group

What is the formation of anti-U?

Answer 23

formed S-s-U in individuals

Question 24

MNS Blood Group

Is anti-U implicated in HDFN and HTR?

Answer 24

yes

Also N-U-patients form anti”N” must receive M+N-S-s-U

Question 25

P Blood Group System | Name the 3 main P system antigens

Answer 25

P P1 PK

Question 26

P Blood Group System | Name the 2 Blood group systems related to the P system

Answer 26

ABH and I

Question 27

``` P Blood Group System What Ig class are P antibodies? ```

Answer 27

IgM

Question 28

P Blood Group System | What is the best reaction temp and medium for P antibodies?

Answer 28

Room Temp and below, Saline

Question 29

P Blood Group System | Do P antibodies Fix complement

Answer 29

Yes

Question 30

P Blood Group System | Are P antibodies implicated in HDFN and HTR?

Answer 30

No

Question 31

P Blood Group System | What disease/condition is associated with Anti-P

Answer 31

Paroxysmal cold hemoglobinuria

Question 32

P Blood Group System | What disease/condition is associated with Anti-P1

Answer 32

Parasitic infections

Question 33

P Blood Group System | What disease/condition is associated with Anti P1Pk?

Answer 33

Spontaneous Abortion in early pregnancy

Question 34

P Blood Group System | Individuals lacking P system Ag's appear to be naturally resistant to infection from _____?

Answer 34

uropathogenic E. coli, parvo-B19 virus

Question 35

P Blood Group System | Describe the effect of storage on the P antigen?

Answer 35

Rapid deterioration

Question 36

Lutheran Blood Group | What are the 2 main antigens in the Lutheran system and their frequency?

Answer 36

``` Lua+ = 8% Lub+ = 99.8% ```

Question 37

Lutheran Blood Group | What is the difference between anti-Lua and anti-Lub?

Answer 37

Anti-Lua is seen occasionally, but anti-Lub is very rare as most people are positive (high frequency Ag). Anti-Lua mixed field reaction

Question 38

``` Lutheran Blood Group What is the Ig class for Lutheran? ```

Answer 38

IgM or IgG for Lua IgG for Lub

Question 39

Lutheran Blood Group | What is the best reaction temp and medium?

Answer 39

Room temp and below, or 37 and AHG

Question 40

Lutheran Blood Group | fixes complement?

Answer 40

Yes some

Question 41

Lutheran Blood Group | Implicated in HDFN and HTR?

Answer 41

Mild since Ag's poorly developed at birth; mild HTR

Question 42

Kell Blood Group System | Identify the name and symbol for each of the 3 pairs of alleles in the Kell system:

Answer 42

``` K - Kell 9%+ k - Cellano 99.8% + Kpa - Penney - 2% Caucasians Kpb - Rautenberg > 99.9%+ Jsa - Sutter 20% Black Jsb - Matthews >99%+ ```