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MDL 216 Blood Bank > Test 2 > Flashcards

Test 2 Flashcards

1
Q

Name the four major ABO blood types:

A

A
B
O
AB

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2
Q

A gene that does not produce any detectable traits; dd = no D antigens = Rh negative

A

Amorph

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3
Q

Forward cell grouping tests

A

RBC antigens

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4
Q

Reverse Cell grouping tests

A

serum for Antibodies

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5
Q

Name the three alleles of the ABO system

A

A
B
H

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6
Q

Name the four phenotypes of the ABO system

A

A
B
O
AB

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7
Q

Name the six genotypes of the ABO system

A 
AA
AO
BB
BO
OO
AB
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8
Q

Name the 2 genes dominant over allele O

A

A

B

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9
Q

Name the gene that is recessive

A

O

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10
Q

Name the co-dominant genes

A

A

B

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11
Q

Why can’t newborns be reverse grouped at birth?

A

Not yet producing antibodies

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12
Q

Name the antigen present on red cells in order for the expression of the ABO antigens

A

H

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13
Q

Name the immunodominant sugar associated with H antigen

A

L-fucose

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14
Q

Name the immunodominant sugar associated with A antigen

A

GalNac

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15
Q

Name the immunodominant sugar associated with B antigen

A

D-galactose

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16
Q

Describe the outcome if a person is hh

A

Bombay, no ABO expression

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17
Q

Describe the outcome if a Bombay person receives O blood

A

hemolytic reaction of O RBCs because of H antigen

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18
Q

Name the two major subgroups of blood type A and their frequency

A 
A1 = 80%
A2 = 20%
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19
Q

Name the lectin used to differentiate between A1 and A2

A

Dolichose bifloris

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20
Q

Name the antibodies associated with each of the four major blood groups

A 
A = anti-B
B = anti-A
O = anti-A, anti-B, anti-A,B
AB = none
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21
Q

When do ABO antibodies develop?

A

3-6 months of age

22
Q

How do ABO antibodies develop?

A

Naturally occurring IgM due to actions of E. coli in the gut. May also develop anti-IgG through pregnancy or transfusion

23
Q

ABO antibodies reaction temp?

A

room temp

24
Q

ABO reaction media

A

saline

25
Q

Will ABO bind complement

A

yes

26
Q

Name two classes of ABO antibodies

A

IgM and IgG

27
Q

6 conditions in which a person may lack ABO antibodies

A 
newborn
elderly
leukemia
hypogammaglobulinemia
immunosuppressed
bone marrow transplant
28
Q

Two other names for serum grouping

A

reverse grouping

back typing

29
Q

Distinguish the A blood group according to their serum grouping

A

A cells neg, B cells 4+ (anti-B)

30
Q

Distinguish the B blood group according to their serum grouping

A

A cells 4+, B cells neg (anti-A)

31
Q

Distinguish the O blood group according to their serum grouping

A

A cells 4+, B cells 4) (anti-A, anti-B, and anti-A,B)

32
Q

Distinguish the AB blood group according to their serum grouping

A

A cells neg, B cells neg (no antibodies formed)

33
Q

An individual who is capable of secreting soluble, glycoprotein ABH-substances into saliva and other body fluids is termed?

A

Secretor

34
Q

Name the secretor gene

A

SeSe, Sese

35
Q

Name the two blood groups involved in secretor status

A

ABO and H

36
Q

Proteins present in plants, usually seeds, which bind specifically to carbohydrate determinants and agglutinate RBCs through their surface of oligosaccharide determinants

A

Lectin

37
Q

Name the H lectin

A

Ulex europaeus

38
Q

Percentage of Us population = secretors

A

80%

39
Q

Name the three sets of allelic genes in the Rh system:

A

Dd, Cc, Ee

40
Q

Fisher-Race uses what nomenclature

A

DCE

41
Q

Weiner uses what nomenclature

A

Rh, hr

42
Q

Rosenfield uses what nomenclature?

A

1-2

43
Q

Name the five common anti-sera used for typing the antigens in the Rh system

A 
Anti-D
Anti-C
Anti-E
Anti-c
Anti-e
44
Q

Describe the biochemistry of the Rh antigens

A

Nonglycosylated proteins; transmembrate polypeptides

45
Q

The following describes what phenotype?
No Rh antigen expression, (—), RBC membrane abnormalities, may have mild compensated hemolytic anemia, reticulocytoses, slight to moderate decrease in H&H, increase in Hgb F, stomatocytosis

A

Rh null

46
Q

The following describes what phenotype?

Weakened antigen expression, clinical symptoms similar to Rh null but less sever

A

Rh mod

47
Q

Do Rh antibodies bind complement?

A

no

48
Q

Can Rh antibodies cross the placenta?

A

yes

49
Q

Most common Rh genotype in caucasians

A

R1r

50
Q

Most common Rh genotype in African Americans

A

R0r

51
Q

The ability of an antigen to stimulate an antibody response is called?

A

immunogenicity

MDL 216 Blood Bank (5 decks)

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